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Imidazotriazines: Spleen Tyrosine Kinase (Syk) Inhibitors Identified by Free-Energy Perturbation (FEP).
Lovering, Frank; Aevazelis, Cristina; Chang, Jeanne; Dehnhardt, Christoph; Fitz, Lori; Han, Seungil; Janz, Kristin; Lee, Julie; Kaila, Neelu; McDonald, Joseph; Moore, William; Moretto, Alessandro; Papaioannou, Nikolaos; Richard, David; Ryan, Mark S; Wan, Zhao-Kui; Thorarensen, Atli.
Affiliation
  • Lovering F; Worldwide Medicinal Chemistry, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA, 02139, USA. frank.lovering@pfizer.com.
  • Aevazelis C; Inflammation and Immunity, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA, 02139, USA.
  • Chang J; Worldwide Medicinal Chemistry, Pfizer Worldwide R&D, Eastern Point Road, Groton, CT, 06340, USA.
  • Dehnhardt C; Worldwide Medicinal Chemistry, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA, 02139, USA.
  • Fitz L; Inflammation and Immunity, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA, 02139, USA.
  • Han S; Worldwide Medicinal Chemistry, Pfizer Worldwide R&D, Eastern Point Road, Groton, CT, 06340, USA.
  • Janz K; Worldwide Medicinal Chemistry, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA, 02139, USA.
  • Lee J; Inflammation and Immunity, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA, 02139, USA.
  • Kaila N; Worldwide Medicinal Chemistry, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA, 02139, USA.
  • McDonald J; Worldwide Medicinal Chemistry, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA, 02139, USA.
  • Moore W; Worldwide Medicinal Chemistry, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA, 02139, USA.
  • Moretto A; Worldwide Medicinal Chemistry, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA, 02139, USA.
  • Papaioannou N; Worldwide Medicinal Chemistry, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA, 02139, USA.
  • Richard D; Worldwide Medicinal Chemistry, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA, 02139, USA.
  • Ryan MS; Inflammation and Immunity, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA, 02139, USA.
  • Wan ZK; Worldwide Medicinal Chemistry, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA, 02139, USA.
  • Thorarensen A; Worldwide Medicinal Chemistry, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA, 02139, USA.
ChemMedChem ; 11(2): 217-33, 2016 Jan 19.
Article in En | MEDLINE | ID: mdl-26381330
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Full text: 1 Database: MEDLINE Main subject: Thermodynamics / Triazines / Protein-Tyrosine Kinases / Intracellular Signaling Peptides and Proteins / Protein Kinase Inhibitors / Imidazoles Type of study: Prognostic_studies Limits: Humans Language: En Journal: ChemMedChem Journal subject: FARMACOLOGIA / QUIMICA Year: 2016 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: Thermodynamics / Triazines / Protein-Tyrosine Kinases / Intracellular Signaling Peptides and Proteins / Protein Kinase Inhibitors / Imidazoles Type of study: Prognostic_studies Limits: Humans Language: En Journal: ChemMedChem Journal subject: FARMACOLOGIA / QUIMICA Year: 2016 Type: Article Affiliation country: United States