Your browser doesn't support javascript.
loading
Helicobacter pylori cagA Promoter Region Sequences Influence CagA Expression and Interleukin 8 Secretion.
Ferreira, Rui M; Pinto-Ribeiro, Ines; Wen, Xiaogang; Marcos-Pinto, Ricardo; Dinis-Ribeiro, Mário; Carneiro, Fátima; Figueiredo, Ceu.
Affiliation
  • Ferreira RM; i3S - Instituto de Investigação e Inovação em Saúde Ipatimup - Institute of Molecular Pathology and Immunology.
  • Pinto-Ribeiro I; i3S - Instituto de Investigação e Inovação em Saúde Ipatimup - Institute of Molecular Pathology and Immunology.
  • Wen X; Ipatimup - Institute of Molecular Pathology and Immunology Centro Hospitalar Vila Nova de Gaia/Espinho, Portugal.
  • Marcos-Pinto R; Institute of Biomedical Sciences Abel Salazar CIDES/CINTESIS Department of Gastroenterology, Centro Hospitalar do Porto.
  • Dinis-Ribeiro M; CIDES/CINTESIS Department of Gastroenterology, IPO.
  • Carneiro F; i3S - Instituto de Investigação e Inovação em Saúde Ipatimup - Institute of Molecular Pathology and Immunology Faculty of Medicine, University of Porto Department of Pathology, Centro Hospitalar São João, Porto.
  • Figueiredo C; i3S - Instituto de Investigação e Inovação em Saúde Ipatimup - Institute of Molecular Pathology and Immunology Faculty of Medicine, University of Porto.
J Infect Dis ; 213(4): 669-73, 2016 Feb 15.
Article in En | MEDLINE | ID: mdl-26401027
ABSTRACT
Heterogeneity at the Helicobacter pylori cagA gene promoter region has been linked to variation in CagA expression and gastric histopathology. Here, we characterized the cagA promoter and expression in 46 H. pylori strains from Portugal. Our results confirm the relationship between cagA promoter region variation and protein expression originally observed in strains from Colombia. We observed that individuals with intestinal metaplasia were all infected with H. pylori strains containing a specific cagA motif. Additionally, we provided novel functional evidence that strain-specific sequences in the cagA promoter region and CagA expression levels influence interleukin 8 secretion by the host gastric epithelial cells.
Subject(s)
Key words
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Database: MEDLINE Main subject: Bacterial Proteins / Gene Expression / Interleukin-8 / Helicobacter pylori / Promoter Regions, Genetic / Antigens, Bacterial Type of study: Observational_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: En Journal: J Infect Dis Year: 2016 Type: Article
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Database: MEDLINE Main subject: Bacterial Proteins / Gene Expression / Interleukin-8 / Helicobacter pylori / Promoter Regions, Genetic / Antigens, Bacterial Type of study: Observational_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: En Journal: J Infect Dis Year: 2016 Type: Article