Assessment of Disease-Related Therapeutic Protein Drug-Drug Interaction for Etrolizumab in Patients With Moderately to Severely Active Ulcerative Colitis.

Wei, Xiaohui; Kenny, Jane R; Dickmann, Leslie; Maciuca, Romeo; Looney, Caroline; Tang, Meina T

Wei, Xiaohui; Kenny, Jane R; Dickmann, Leslie; Maciuca, Romeo; Looney, Caroline; Tang, Meina T.

Affiliation

Wei X; Clinical Pharmacology, Genentech, Inc, South San Francisco, CA, USA.
Kenny JR; Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USA.
Dickmann L; Clinical Pharmacology, Genentech, Inc, South San Francisco, CA, USA.
Maciuca R; Biometrics, Genentech, Inc, South San Francisco, CA, USA.
Looney C; Biomarkers, Genentech, Inc, South San Francisco, CA, 94080, USA.
Tang MT; Clinical Pharmacology, Genentech, Inc, South San Francisco, CA, USA.

J Clin Pharmacol ; 56(6): 693-704, 2016 06.

Article in En | MEDLINE | ID: mdl-26412221

Subject(s)

Antibodies, Monoclonal, Humanized/metabolism; C-Reactive Protein/metabolism; Colitis, Ulcerative/drug therapy; Colitis, Ulcerative/metabolism; Cytochrome P-450 CYP3A/metabolism; Severity of Illness Index; Antibodies, Monoclonal, Humanized/therapeutic use; Colitis, Ulcerative/diagnosis; Cytokines/metabolism; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions/physiology; Humans; Internationality; Protein Binding/physiology

Key words

etrolizumab; therapeutic protein drug-drug interaction; ulcerative colitis

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Full text: 1 Database: MEDLINE Main subject: Severity of Illness Index / C-Reactive Protein / Colitis, Ulcerative / Cytochrome P-450 CYP3A / Antibodies, Monoclonal, Humanized Type of study: Clinical_trials / Diagnostic_studies Limits: Humans Language: En Journal: J Clin Pharmacol Year: 2016 Type: Article Affiliation country: United States

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