'Emergency exit' of bone-marrow-resident CD34(+)DNAM-1(bright)CXCR4(+)-committed lymphoid precursors during chronic infection and inflammation.
Nat Commun
; 6: 8109, 2015 Oct 05.
Article
in En
| MEDLINE
| ID: mdl-26436997
ABSTRACT
During chronic inflammatory disorders, a persistent natural killer (NK) cell derangement is observed. While increased cell turnover is expected, little is known about whether and how NK-cell homeostatic balance is maintained. Here, flow cytometric analysis of peripheral blood mononuclear cells in chronic inflammatory disorders, both infectious and non-infectious, reveals the presence of a CD34(+)CD226(DNAM-1)(bright)CXCR4(+) cell population displaying transcriptional signatures typical of common lymphocyte precursors and giving rise to NK-cell progenies with high expression of activating receptors and mature function and even to α/ß T lymphocytes. CD34(+)CD226(bright)CXCR4(+) cells reside in bone marrow, hardly circulate in healthy donors and are absent in cord blood. Their proportion correlates with the degree of inflammation, reflecting lymphoid cell turnover/reconstitution during chronic inflammation. These findings provide insight on intermediate stages of NK-cell development, a view of emergency recruitment of cell precursors, and upgrade our understanding and monitoring of chronic inflammatory conditions.
Full text:
1
Database:
MEDLINE
Main subject:
Tuberculosis, Pulmonary
/
Bone Marrow Cells
/
Leukocytes, Mononuclear
/
Killer Cells, Natural
/
HIV Infections
/
Hepatitis C, Chronic
/
Pulmonary Disease, Chronic Obstructive
/
Lymphoid Progenitor Cells
Type of study:
Clinical_trials
/
Observational_studies
Limits:
Humans
Language:
En
Journal:
Nat Commun
Journal subject:
BIOLOGIA
/
CIENCIA
Year:
2015
Type:
Article
Affiliation country:
Italy