Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency.

Walter, Jolan E; Rosen, Lindsey B; Csomos, Krisztian; Rosenberg, Jacob M; Mathew, Divij; Keszei, Marton; Ujhazi, Boglarka; Chen, Karin; Lee, Yu Nee; Tirosh, Irit; Dobbs, Kerry; Al-Herz, Waleed; Cowan, Morton J; Puck, Jennifer; Bleesing, Jack J; Grimley, Michael S; Malech, Harry; De Ravin, Suk See; Gennery, Andrew R; Abraham, Roshini S; Joshi, Avni Y; Boyce, Thomas G; Butte, Manish J; Nadeau, Kari C; Balboni, Imelda; Sullivan, Kathleen E; Akhter, Javeed; Adeli, Mehdi; El-Feky, Reem A; El-Ghoneimy, Dalia H; Dbaibo, Ghassan; Wakim, Rima; Azzari, Chiara; Palma, Paolo; Cancrini, Caterina; Capuder, Kelly; Condino-Neto, Antonio; Costa-Carvalho, Beatriz T; Oliveira, Joao Bosco; Roifman, Chaim; Buchbinder, David; Kumanovics, Attila; Franco, Jose Luis; Niehues, Tim; Schuetz, Catharina; Kuijpers, Taco; Yee, Christina; Chou, Janet; Masaad, Michel J; Geha, Raif

Walter, Jolan E; Rosen, Lindsey B; Csomos, Krisztian; Rosenberg, Jacob M; Mathew, Divij; Keszei, Marton; Ujhazi, Boglarka; Chen, Karin; Lee, Yu Nee; Tirosh, Irit; Dobbs, Kerry; Al-Herz, Waleed; Cowan, Morton J; Puck, Jennifer; Bleesing, Jack J; Grimley, Michael S; Malech, Harry; De Ravin, Suk See; Gennery, Andrew R; Abraham, Roshini S; Joshi, Avni Y; Boyce, Thomas G; Butte, Manish J; Nadeau, Kari C; Balboni, Imelda; Sullivan, Kathleen E; Akhter, Javeed; Adeli, Mehdi; El-Feky, Reem A; El-Ghoneimy, Dalia H; Dbaibo, Ghassan; Wakim, Rima; Azzari, Chiara; Palma, Paolo; Cancrini, Caterina; Capuder, Kelly; Condino-Neto, Antonio; Costa-Carvalho, Beatriz T; Oliveira, Joao Bosco; Roifman, Chaim; Buchbinder, David; Kumanovics, Attila; Franco, Jose Luis; Niehues, Tim; Schuetz, Catharina; Kuijpers, Taco; Yee, Christina; Chou, Janet; Masaad, Michel J; Geha, Raif.

J Clin Invest ; 125(11): 4135-48, 2015 Nov 02.

Article in En | MEDLINE | ID: mdl-26457731

Subject(s)

Autoantibodies/immunology; Autoantigens/immunology; Autoimmune Diseases/immunology; Cytokines/immunology; DNA-Binding Proteins/deficiency; Granulomatous Disease, Chronic/immunology; Homeodomain Proteins/immunology; Nuclear Proteins/deficiency; Severe Combined Immunodeficiency/immunology; Adolescent; Adult; Animals; Antibodies, Neutralizing/blood; Antibodies, Neutralizing/immunology; Antibody Specificity; Autoantibodies/blood; Autoimmune Diseases/genetics; Child; Child, Preschool; DEAD-box RNA Helicases/immunology; DNA-Binding Proteins/genetics; Disease Models, Animal; Female; Granulomatous Disease, Chronic/genetics; Granulomatous Disease, Chronic/therapy; Homeodomain Proteins/genetics; Humans; Infant; Interferon-Induced Helicase, IFIH1; Male; Mice; Mice, Inbred Strains; Nuclear Proteins/genetics; Severe Combined Immunodeficiency/genetics; Severe Combined Immunodeficiency/therapy; Toll-Like Receptors/agonists; Toll-Like Receptors/immunology; Virus Diseases/immunology; Young Adult

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Full text: 1 Database: MEDLINE Main subject: Autoantibodies / Autoantigens / Autoimmune Diseases / Nuclear Proteins / Cytokines / Severe Combined Immunodeficiency / Homeodomain Proteins / DNA-Binding Proteins / Granulomatous Disease, Chronic Type of study: Prognostic_studies Limits: Adolescent / Adult / Animals / Child / Child, preschool / Female / Humans / Infant / Male Language: En Journal: J Clin Invest Year: 2015 Type: Article

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