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DNA-binding-domain fusions enhance the targeting range and precision of Cas9.
Bolukbasi, Mehmet Fatih; Gupta, Ankit; Oikemus, Sarah; Derr, Alan G; Garber, Manuel; Brodsky, Michael H; Zhu, Lihua Julie; Wolfe, Scot A.
Affiliation
  • Bolukbasi MF; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Gupta A; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Oikemus S; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Derr AG; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Garber M; Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Brodsky MH; Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Zhu LJ; Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Wolfe SA; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Nat Methods ; 12(12): 1150-6, 2015 Dec.
Article in En | MEDLINE | ID: mdl-26480473
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Full text: 1 Database: MEDLINE Main subject: Gene Targeting / DNA-Binding Proteins / CRISPR-Associated Proteins / Clustered Regularly Interspaced Short Palindromic Repeats / CRISPR-Cas Systems Limits: Humans Language: En Journal: Nat Methods Journal subject: TECNICAS E PROCEDIMENTOS DE LABORATORIO Year: 2015 Type: Article Affiliation country: United States
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Gene Targeting / DNA-Binding Proteins / CRISPR-Associated Proteins / Clustered Regularly Interspaced Short Palindromic Repeats / CRISPR-Cas Systems Limits: Humans Language: En Journal: Nat Methods Journal subject: TECNICAS E PROCEDIMENTOS DE LABORATORIO Year: 2015 Type: Article Affiliation country: United States