Causes of neuropathy in patients referred as "idiopathic neuropathy".
Muscle Nerve
; 53(6): 856-61, 2016 06.
Article
in En
| MEDLINE
| ID: mdl-26561790
ABSTRACT
INTRODUCTION:
The etiology of neuropathy was idiopathic in 20%-30% of patients despite thorough investigation, based on results from the 1980s and 1990s. Since then, new etiologies have been recognized, and skin biopsy has been used to confirm small-fiber neuropathy.METHODS:
The authors reviewed the charts of 373 patients with idiopathic neuropathy who were referred to a neuropathy center between 2002 and 2012.RESULTS:
Among the 284 eligible patients, 93 (32.7%) remained idiopathic. The most common cause was impaired glucose metabolism (72 patients, 25.3%), including diabetes in 26 and prediabetes in 46. Other etiologies were chronic inflammatory demyelinating polyneuropathy (CIDP) in 57 (20%) and monoclonal gammopathy in 20 (7%), as well as toxic, Sjögren disease, celiac disease, other immune-mediated diseases, vitamin B12 deficiency, amyloidosis, vitamin B1 and B6 deficiency, vasculitis, hypothyroidism, hereditary, Lyme disease, and anti-sulfatide antibody.CONCLUSIONS:
The major causes of undiagnosed neuropathies were impaired glucose metabolism, CIDP, and monoclonal gammopathies. Despite thorough evaluation 32.7% remained idiopathic. Muscle Nerve 53 856-861, 2016.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Paraproteinemias
/
Peripheral Nervous System Diseases
/
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
Type of study:
Etiology_studies
/
Observational_studies
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Muscle Nerve
Year:
2016
Type:
Article
Affiliation country:
United States