Halogen Exchange Reaction of Aliphatic Fluorine Compounds with Organic Halides as Halogen Source.
Org Lett
; 17(24): 5942-5, 2015 Dec 18.
Article
in En
| MEDLINE
| ID: mdl-26629792
ABSTRACT
The halogen exchange reaction of aliphatic fluorine compounds with organic halides as the halogen source was achieved. Treatment of alkyl fluorides (primary, secondary, or tertiary fluorides) with a catalytic amount of titanocene dihalides, trialkyl aluminum, and polyhalomethanes (chloro or bromo methanes) as the halogen source gave the corresponding alkyl halides in excellent yields under mild conditions. In the case of a fluorine/iodine exchange, no titanocene catalyst is needed. Only C-F bonds are selectively activated under these conditions, whereas alkyl chlorides, bromides, and iodides are tolerant to these reactions.
Full text:
1
Database:
MEDLINE
Language:
En
Journal:
Org Lett
Journal subject:
BIOQUIMICA
Year:
2015
Type:
Article
Affiliation country:
Japan