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Gene-based pleiotropy across migraine with aura and migraine without aura patient groups.
Zhao, Huiying; Eising, Else; de Vries, Boukje; Vijfhuizen, Lisanne S; Anttila, Verneri; Winsvold, Bendik S; Kurth, Tobias; Stefansson, Hreinn; Kallela, Mikko; Malik, Rainer; Stam, Anine H; Ikram, M Arfan; Ligthart, Lannie; Freilinger, Tobias; Alexander, Michael; Müller-Myhsok, Bertram; Schreiber, Stefan; Meitinger, Thomas; Aromas, Arpo; Eriksson, Johan G; Boomsma, Dorret I; van Duijn, Cornelia M; Zwart, John-Anker; Quaye, Lydia; Kubisch, Christian; Dichgans, Martin; Wessman, Maija; Stefansson, Kari; Chasman, Daniel I; Palotie, Aarno; Martin, Nicholas G; Montgomery, Grant W; Ferrari, Michel D; Terwindt, Gisela M; van den Maagdenberg, Arn M J M; Nyholt, Dale R.
Affiliation
  • Zhao H; Institute of Health and Biomedical Innovation, Queensland University of Technology, Australia QIMR Berghofer Medical Research Institute, Brisbane, Australia.
  • Eising E; Department of Human Genetics, Leiden University Medical Centre, The Netherlands.
  • de Vries B; Department of Human Genetics, Leiden University Medical Centre, The Netherlands.
  • Vijfhuizen LS; Department of Human Genetics, Leiden University Medical Centre, The Netherlands.
  • Anttila V; Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, USA Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, USA Harvard Medical School, USA Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, USA.
  • Winsvold BS; FORMI and Department of Neurology, Oslo University Hospital and University of Oslo, Norway.
  • Kurth T; Institut National de la Santé et de la Recherche Médicale (INSERM) Research Center for Epidemiology and Biostatistics (U897) - Team Neuroepidemiology, France University of Bordeaux, France Department of Medicine, Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School,
  • Stefansson H; deCODE Genetics, Iceland.
  • Kallela M; Department of Neurology, Helsinki University Central Hospital, Finland.
  • Malik R; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Germany.
  • Stam AH; Department of Neurology, Leiden University Medical Centre, The Netherlands.
  • Ikram MA; Department of Epidemiology, Erasmus University Medical Centre, The Netherlands Department of Radiology, Erasmus University Medical Centre, The Netherlands Department of Neurology, Erasmus University Medical Centre, The Netherlands.
  • Ligthart L; Department of Biological Psychology, VU University, The Netherlands EMGO+ Institute for Health and Care Research, VU University Medical Centre, The Netherlands.
  • Freilinger T; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Germany Department of Neurology and Epileptology and Hertie-Institute for Clinical Brain Research, University of Tuebingen, Germany.
  • Alexander M; Department of Genomics, Life & Brain Center, University of Bonn, Germany Institute of Human Genetics, University of Bonn, Germany.
  • Müller-Myhsok B; Max Planck Institute of Psychiatry, Germany Munich Cluster for Systems Neurology (SyNergy), Germany.
  • Schreiber S; Institute of Clinical Molecular Biology, Christian Albrechts University, Germany Department of Internal Medicine I, Christian Albrechts University, Germany.
  • Meitinger T; Institute of Human Genetics, Helmholtz Center Munich, Germany Institute of Human Genetics, Klinikum Rechts der Isar, Technische Universität München, Germany.
  • Aromas A; National Institute for Health and Welfare, Finland.
  • Eriksson JG; National Institute for Health and Welfare, Finland Institute of Genetics, Folkhälsan Research Center, Finland Department of General Practice, Helsinki University Central Hospital, Finland Vaasa Central Hospital, Finland Department of General Practice and Primary Health Care, University of Helsinki,
  • Boomsma DI; Department of Biological Psychology, VU University, The Netherlands.
  • van Duijn CM; Department of Epidemiology, Erasmus University Medical Centre, The Netherlands.
  • Zwart JA; FORMI and Department of Neurology, Oslo University Hospital and University of Oslo, Norway.
  • Quaye L; Department of Twin Research and Genetic Epidemiology, King's College London, UK.
  • Kubisch C; Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Germany.
  • Dichgans M; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Germany Munich Cluster for Systems Neurology (SyNergy), Germany.
  • Wessman M; Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, USA Institute of Genetics, Folkhälsan Research Center, Finland.
  • Stefansson K; deCODE Genetics, Iceland School of Medicine, University of Iceland, Iceland.
  • Chasman DI; Institute of Health and Biomedical Innovation, Queensland University of Technology, Australia.
  • Palotie A; Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, USA Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, USA Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, USA Institute for Molecular Medicin
  • Martin NG; QIMR Berghofer Medical Research Institute, Brisbane, Australia.
  • Montgomery GW; QIMR Berghofer Medical Research Institute, Brisbane, Australia.
  • Ferrari MD; Department of Neurology, Leiden University Medical Centre, The Netherlands.
  • Terwindt GM; Department of Neurology, Leiden University Medical Centre, The Netherlands.
  • van den Maagdenberg AM; Department of Human Genetics, Leiden University Medical Centre, The Netherlands Department of Neurology, Leiden University Medical Centre, The Netherlands.
  • Nyholt DR; Institute of Health and Biomedical Innovation, Queensland University of Technology, Australia QIMR Berghofer Medical Research Institute, Brisbane, Australia d.nyholt@qut.edu.au.
Cephalalgia ; 36(7): 648-57, 2016 Jun.
Article in En | MEDLINE | ID: mdl-26660531
ABSTRACT

INTRODUCTION:

It is unclear whether patients diagnosed according to International Classification of Headache Disorders criteria for migraine with aura (MA) and migraine without aura (MO) experience distinct disorders or whether their migraine subtypes are genetically related.

AIM:

Using a novel gene-based (statistical) approach, we aimed to identify individual genes and pathways associated both with MA and MO.

METHODS:

Gene-based tests were performed using genome-wide association summary statistic results from the most recent International Headache Genetics Consortium study comparing 4505 MA cases with 34,813 controls and 4038 MO cases with 40,294 controls. After accounting for non-independence of gene-based test results, we examined the significance of the proportion of shared genes associated with MA and MO.

RESULTS:

We found a significant overlap in genes associated with MA and MO. Of the total 1514 genes with a nominally significant gene-based p value (pgene-based ≤ 0.05) in the MA subgroup, 107 also produced pgene-based ≤ 0.05 in the MO subgroup. The proportion of overlapping genes is almost double the empirically derived null expectation, producing significant evidence of gene-based overlap (pleiotropy) (pbinomial-test = 1.5 × 10(-4)). Combining results across MA and MO, six genes produced genome-wide significant gene-based p values. Four of these genes (TRPM8, UFL1, FHL5 and LRP1) were located in close proximity to previously reported genome-wide significant SNPs for migraine, while two genes, TARBP2 and NPFF separated by just 259 bp on chromosome 12q13.13, represent a novel risk locus. The genes overlapping in both migraine types were enriched for functions related to inflammation, the cardiovascular system and connective tissue.

CONCLUSIONS:

Our results provide novel insight into the likely genes and biological mechanisms that underlie both MA and MO, and when combined with previous data, highlight the neuropeptide FF-amide peptide encoding gene (NPFF) as a novel candidate risk gene for both types of migraine.
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Full text: 1 Database: MEDLINE Main subject: Receptors, Neuropeptide / Migraine with Aura / Migraine without Aura / Genetic Pleiotropy Type of study: Prognostic_studies Limits: Adult / Female / Humans / Male Language: En Journal: Cephalalgia Year: 2016 Type: Article Affiliation country: Australia
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Receptors, Neuropeptide / Migraine with Aura / Migraine without Aura / Genetic Pleiotropy Type of study: Prognostic_studies Limits: Adult / Female / Humans / Male Language: En Journal: Cephalalgia Year: 2016 Type: Article Affiliation country: Australia