Molecular basis and functional significance of Angiotensin II-induced increase in Discoidin Domain Receptor 2 gene expression in cardiac fibroblasts.

George, Mereena; Vijayakumar, Anupama; Dhanesh, Sivadasan Bindu; James, Jackson; Shivakumar, K

George, Mereena; Vijayakumar, Anupama; Dhanesh, Sivadasan Bindu; James, Jackson; Shivakumar, K.

Affiliation

George M; Division of Cellular and Molecular Cardiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, 695011, Kerala, India.
Vijayakumar A; Division of Cellular and Molecular Cardiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, 695011, Kerala, India.
Dhanesh SB; Neuro Stem Cell Biology, Neurobiology Division, Rajiv Gandhi Center for Biotechnology, Trivandrum, 695014, Kerala, India.
James J; Neuro Stem Cell Biology, Neurobiology Division, Rajiv Gandhi Center for Biotechnology, Trivandrum, 695014, Kerala, India.
Shivakumar K; Division of Cellular and Molecular Cardiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, 695011, Kerala, India. Electronic address: shivak@sctimst.ac.in.

J Mol Cell Cardiol ; 90: 59-69, 2016 Jan.

Article in En | MEDLINE | ID: mdl-26674152

Subject(s)

Angiotensin II/pharmacology; Collagen Type I/genetics; Fibroblasts/drug effects; Myocardium/metabolism; Receptor Protein-Tyrosine Kinases/genetics; Receptors, Mitogen/genetics; Angiotensin II/genetics; Angiotensin II/metabolism; Animals; Collagen Type I/antagonists & inhibitors; Collagen Type I/metabolism; Discoidin Domain Receptors; Enzyme Inhibitors/pharmacology; Fibroblasts/cytology; Fibroblasts/metabolism; Gene Expression Regulation; Male; Mitogen-Activated Protein Kinase 1/genetics; Mitogen-Activated Protein Kinase 1/metabolism; Mitogen-Activated Protein Kinase 3/genetics; Mitogen-Activated Protein Kinase 3/metabolism; Myocardium/cytology; NADPH Oxidases/genetics; NADPH Oxidases/metabolism; NF-kappa B/genetics; NF-kappa B/metabolism; Primary Cell Culture; Protein Kinase C/genetics; Protein Kinase C/metabolism; RNA, Small Interfering/genetics; RNA, Small Interfering/metabolism; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species/metabolism; Receptor Protein-Tyrosine Kinases/antagonists & inhibitors; Receptor Protein-Tyrosine Kinases/metabolism; Receptors, Mitogen/antagonists & inhibitors; Receptors, Mitogen/metabolism; Signal Transduction; Transcription, Genetic; Type C Phospholipases/genetics; Type C Phospholipases/metabolism; p38 Mitogen-Activated Protein Kinases/genetics; p38 Mitogen-Activated Protein Kinases/metabolism

Key words

Angiotensin II; Cardiac fibroblasts; Collagen type I; Discoidin domain receptor 2; NF-κB; p38 MAPK

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Full text: 1 Database: MEDLINE Main subject: Angiotensin II / Receptors, Mitogen / Receptor Protein-Tyrosine Kinases / Collagen Type I / Fibroblasts / Myocardium Language: En Journal: J Mol Cell Cardiol Year: 2016 Type: Article Affiliation country: India

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