BMI1 induces an invasive signature in melanoma that promotes metastasis and chemoresistance.

Ferretti, Roberta; Bhutkar, Arjun; McNamara, Molly C; Lees, Jacqueline A

Ferretti, Roberta; Bhutkar, Arjun; McNamara, Molly C; Lees, Jacqueline A.

Affiliation

Ferretti R; David H. Koch Institute for Integrative Cancer Research, Cambridge, Massachusetts 02139, USA;
Bhutkar A; David H. Koch Institute for Integrative Cancer Research, Cambridge, Massachusetts 02139, USA;
McNamara MC; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Lees JA; David H. Koch Institute for Integrative Cancer Research, Cambridge, Massachusetts 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

Genes Dev ; 30(1): 18-33, 2016 Jan 01.

Article in En | MEDLINE | ID: mdl-26679841

Subject(s)

Drug Resistance, Neoplasm/genetics; Melanoma/genetics; Melanoma/physiopathology; Polycomb Repressive Complex 1/metabolism; Animals; Antineoplastic Agents/pharmacology; Antineoplastic Agents/therapeutic use; Cell Line, Tumor; Cell Survival/genetics; Gene Expression Regulation, Neoplastic/drug effects; Humans; Melanoma/diagnosis; Melanoma/drug therapy; Mice; Neoplasm Invasiveness/genetics; Polycomb Repressive Complex 1/genetics; Prognosis; Proto-Oncogene Proteins B-raf/antagonists & inhibitors; Skin Neoplasms; Melanoma, Cutaneous Malignant

Key words

BMI1; invasive signature; melanoma; metastases; therapeutic resistance

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Full text: 1 Database: MEDLINE Main subject: Drug Resistance, Neoplasm / Polycomb Repressive Complex 1 / Melanoma Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Genes Dev Journal subject: BIOLOGIA MOLECULAR Year: 2016 Type: Article

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