Mapping the Aggregation Kinetics of a Therapeutic Antibody Fragment.

Chakroun, Nesrine; Hilton, David; Ahmad, Shahina S; Platt, Geoffrey W; Dalby, Paul A

Chakroun, Nesrine; Hilton, David; Ahmad, Shahina S; Platt, Geoffrey W; Dalby, Paul A.

Affiliation

Chakroun N; EPSRC Centre for Innovative Manufacturing in Emergent Macromolecular Therapies, Department of Biochemical Engineering, University College London , London WC1H 0AH, U.K.
Hilton D; Department of Biochemical Engineering, University College London , London WC1H 0AH, U.K.
Ahmad SS; EPSRC Centre for Innovative Manufacturing in Emergent Macromolecular Therapies, Department of Biochemical Engineering, University College London , London WC1H 0AH, U.K.
Platt GW; Department of Biochemical Engineering, University College London , London WC1H 0AH, U.K.
Dalby PA; Department of Biochemical Engineering, University College London , London WC1H 0AH, U.K.

Mol Pharm ; 13(2): 307-19, 2016 Feb 01.

Article in En | MEDLINE | ID: mdl-26692229

Subject(s)

Antibodies, Monoclonal/chemistry; Immunoglobulin Fragments/chemistry; Membrane Glycoproteins/chemistry; Protein Aggregates; Protein Multimerization; Calorimetry, Differential Scanning; Circular Dichroism; Humans; Hydrogen-Ion Concentration; Kinetics; Protein Conformation; Protein Stability

Key words

aggregation kinetics; antibody fragment; protein aggregation; protein formulation

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Full text: 1 Database: MEDLINE Main subject: Immunoglobulin Fragments / Membrane Glycoproteins / Protein Multimerization / Protein Aggregates / Antibodies, Monoclonal Limits: Humans Language: En Journal: Mol Pharm Journal subject: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Year: 2016 Type: Article Affiliation country: United kingdom

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