Conivaptan, a Selective Arginine Vasopressin V1a and V2 Receptor Antagonist Attenuates Global Cerebral Edema Following Experimental Cardiac Arrest via Perivascular Pool of Aquaporin-4.

Nakayama, Shin; Amiry-Moghaddam, Mahmood; Ottersen, Ole Petter; Bhardwaj, Anish

Nakayama, Shin; Amiry-Moghaddam, Mahmood; Ottersen, Ole Petter; Bhardwaj, Anish.

Affiliation

Nakayama S; Departments of Neurology, Neurological Surgery and Anesthesiology & Peri-Operative Medicine, Oregon Health and Science University, Portland, OR, USA.
Amiry-Moghaddam M; Department of Anesthesiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Ottersen OP; Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Bhardwaj A; Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.

Neurocrit Care ; 24(2): 273-82, 2016 Apr.

Article in En | MEDLINE | ID: mdl-26732270

Subject(s)

Antidiuretic Hormone Receptor Antagonists/pharmacology; Aquaporin 4/metabolism; Benzazepines/pharmacology; Brain Edema/drug therapy; Heart Arrest/complications; Animals; Antidiuretic Hormone Receptor Antagonists/administration & dosage; Benzazepines/administration & dosage; Brain Edema/etiology; Cardiopulmonary Resuscitation; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL

Key words

Aquaporins; Cardiac arrest; Cerebral edema; Conivaptan; Global cerebral ischemia

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Full text: 1 Database: MEDLINE Main subject: Benzazepines / Brain Edema / Aquaporin 4 / Antidiuretic Hormone Receptor Antagonists / Heart Arrest Type of study: Etiology_studies Limits: Animals Language: En Journal: Neurocrit Care Journal subject: NEUROLOGIA / TERAPIA INTENSIVA Year: 2016 Type: Article Affiliation country: United States

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