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Strategically Timing Inhibition of Phosphatidylinositol 3-Kinase to Maximize Therapeutic Index in Estrogen Receptor Alpha-Positive, PIK3CA-Mutant Breast Cancer.
Yang, Wei; Hosford, Sarah R; Dillon, Lloye M; Shee, Kevin; Liu, Stephanie C; Bean, Jennifer R; Salphati, Laurent; Pang, Jodie; Zhang, Xiaolin; Nannini, Michelle A; Demidenko, Eugene; Bates, Darcy; Lewis, Lionel D; Marotti, Jonathan D; Eastman, Alan R; Miller, Todd W.
Affiliation
  • Yang W; Department of Pharmacology and Toxicology, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.
  • Hosford SR; Department of Pharmacology and Toxicology, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.
  • Dillon LM; Department of Pharmacology and Toxicology, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.
  • Shee K; Department of Pharmacology and Toxicology, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.
  • Liu SC; Department of Pharmacology and Toxicology, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.
  • Bean JR; Department of Pharmacology and Toxicology, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.
  • Salphati L; Departments of Drug Metabolism and Pharmacokinetics, South San Francisco, California.
  • Pang J; Departments of Drug Metabolism and Pharmacokinetics, South San Francisco, California.
  • Zhang X; Departments of Drug Metabolism and Pharmacokinetics, South San Francisco, California.
  • Nannini MA; Translational Oncology, Genentech, Inc., South San Francisco, California.
  • Demidenko E; Department of Community and Family Medicine, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.
  • Bates D; Department of Medicine, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.
  • Lewis LD; Department of Medicine, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.
  • Marotti JD; Department of Pathology, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire. Comprehensive Breast Program, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.
  • Eastman AR; Department of Pharmacology and Toxicology, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.
  • Miller TW; Department of Pharmacology and Toxicology, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire. Comprehensive Breast Program, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire. Todd.W.Miller@Dartmouth.edu.
Clin Cancer Res ; 22(9): 2250-60, 2016 05 01.
Article in En | MEDLINE | ID: mdl-26733612
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Full text: 1 Database: MEDLINE Main subject: Breast Neoplasms / Estrogen Receptor alpha / Protein Kinase Inhibitors / Class I Phosphatidylinositol 3-Kinases / Phosphoinositide-3 Kinase Inhibitors / Mutation Limits: Animals / Female / Humans Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2016 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Breast Neoplasms / Estrogen Receptor alpha / Protein Kinase Inhibitors / Class I Phosphatidylinositol 3-Kinases / Phosphoinositide-3 Kinase Inhibitors / Mutation Limits: Animals / Female / Humans Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2016 Type: Article