The Dendritic Cell Major Histocompatibility Complex II (MHC II) Peptidome Derives from a Variety of Processing Pathways and Includes Peptides with a Broad Spectrum of HLA-DM Sensitivity.

Clement, Cristina C; Becerra, Aniuska; Yin, Liusong; Zolla, Valerio; Huang, Liling; Merlin, Simone; Follenzi, Antonia; Shaffer, Scott A; Stern, Lawrence J; Santambrogio, Laura

Clement, Cristina C; Becerra, Aniuska; Yin, Liusong; Zolla, Valerio; Huang, Liling; Merlin, Simone; Follenzi, Antonia; Shaffer, Scott A; Stern, Lawrence J; Santambrogio, Laura.

Affiliation

Clement CC; From the Departments of Pathology and.
Becerra A; the Departments of Pathology and.
Yin L; the Departments of Pathology and.
Zolla V; From the Departments of Pathology and.
Huang L; From the Departments of Pathology and.
Merlin S; the School of Medicine, University of Piemonte Orientale, 28100 Novara, Italy.
Follenzi A; From the Departments of Pathology and; the School of Medicine, University of Piemonte Orientale, 28100 Novara, Italy.
Shaffer SA; Biochemistry and Molecular Pharmacology and; the Proteomics and Mass Spectrometry Facility, University of Massachusetts Medical School, Worcester, Massachusetts 01655, and.
Stern LJ; the Departments of Pathology and; Biochemistry and Molecular Pharmacology and.
Santambrogio L; From the Departments of Pathology and; Microbiology and Immunology, Albert Einstein College of Medicine, New York, New York 10461,. Electronic address: laura.santambrogio@einstein.yu.edu.

J Biol Chem ; 291(11): 5576-5595, 2016 Mar 11.

Article in En | MEDLINE | ID: mdl-26740625

Subject(s)

Dendritic Cells/metabolism; HLA-DR1 Antigen/metabolism; Peptides/metabolism; Proteome/metabolism; Amino Acid Sequence; Animals; Cells, Cultured; Collagen Type II/chemistry; Collagen Type II/metabolism; Complement C3/chemistry; Complement C3/metabolism; Dendritic Cells/chemistry; Gelsolin/chemistry; Gelsolin/metabolism; HLA-DR1 Antigen/chemistry; Humans; Lymph/metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; Molecular Sequence Data; Peptides/chemistry; Protein Binding; Proteome/chemistry; Proteomics; Signal Transduction; Thymosin/chemistry; Thymosin/metabolism

Key words

antigen presentation; antigen processing; dendritic cell; immunological tolerance; lymph; major histocompatibility complex (MHC); proteomics; tolerance

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Full text: 1 Database: MEDLINE Main subject: Peptides / Dendritic Cells / HLA-DR1 Antigen / Proteome Type of study: Diagnostic_studies Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2016 Type: Article

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