Lipid regulators of Pkh2 in Candida albicans, the protein kinase ortholog of mammalian PDK1.

Pastor-Flores, Daniel; Schulze, Jörg O; Bahí, Anna; Süß, Evelyn; Casamayor, Antonio; Biondi, Ricardo M

Pastor-Flores, Daniel; Schulze, Jörg O; Bahí, Anna; Süß, Evelyn; Casamayor, Antonio; Biondi, Ricardo M.

Affiliation

Pastor-Flores D; Research Group PhosphoSites, Medizinische Klinik 1, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
Schulze JO; Research Group PhosphoSites, Medizinische Klinik 1, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
Bahí A; Departament de Bioquímica i Biologia Molecular, Facultat de Veterinària, Universitat Autònoma de Barcelona, Cerdanyola, 08193, Barcelona, Spain; Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, Cerdanyola, 08193, Barcelona, Spain.
Süß E; Research Group PhosphoSites, Medizinische Klinik 1, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
Casamayor A; Departament de Bioquímica i Biologia Molecular, Facultat de Veterinària, Universitat Autònoma de Barcelona, Cerdanyola, 08193, Barcelona, Spain; Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, Cerdanyola, 08193, Barcelona, Spain. Electronic address: antonio.casamayor@uab.
Biondi RM; Research Group PhosphoSites, Medizinische Klinik 1, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany. Electronic address: biondi@med.uni-frankfurt.de.

Biochim Biophys Acta ; 1861(3): 249-59, 2016 Mar.

Article in En | MEDLINE | ID: mdl-26743850

Subject(s)

3-Phosphoinositide-Dependent Protein Kinases/metabolism; Candida albicans/enzymology; Fungal Proteins/metabolism; Lipid Metabolism; 3-Phosphoinositide-Dependent Protein Kinases/genetics; Amino Acid Sequence; Binding Sites; Candida albicans/genetics; Computational Biology; HEK293 Cells; Humans; Models, Molecular; Molecular Sequence Data; Phosphatidic Acids/metabolism; Phosphatidylinositol 4,5-Diphosphate/metabolism; Phosphatidylinositol Phosphates/metabolism; Phosphatidylserines/metabolism; Protein Binding; Protein Structure, Tertiary; Sphingosine/analogs & derivatives; Sphingosine/metabolism; Structure-Activity Relationship; Sulfoglycosphingolipids/metabolism; Transfection

Key words

Allostery; Budding yeast; C. albicans; Cell wall integrity; DHS; PDK1; PHS; PI(3,4)P(2); PI(3,4,5)P(3); PI(4,5)P(2); PIP(3); Phosphatidic acid; Phosphatidylcholine; Phosphatidylethanolamine; Phosphatidylserine; Pkh; Sphingosine; Sulfatide

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Full text: 1 Database: MEDLINE Main subject: Candida albicans / Fungal Proteins / Lipid Metabolism / 3-Phosphoinositide-Dependent Protein Kinases Limits: Humans Language: En Journal: Biochim Biophys Acta Year: 2016 Type: Article Affiliation country: Germany

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