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Activation of the cAMP/protein kinase A signalling pathway by coronin 1 is regulated by cyclin-dependent kinase 5 activity.
Liu, Xiaolong; BoseDasgupta, Somdeb; Jayachandran, Rajesh; Studer, Vera; Rühl, Sebastian; Stiess, Michael; Pieters, Jean.
Affiliation
  • Liu X; Biozentrum, University of Basel, Switzerland.
  • BoseDasgupta S; Biozentrum, University of Basel, Switzerland.
  • Jayachandran R; Biozentrum, University of Basel, Switzerland.
  • Studer V; Biozentrum, University of Basel, Switzerland.
  • Rühl S; Biozentrum, University of Basel, Switzerland.
  • Stiess M; Biozentrum, University of Basel, Switzerland.
  • Pieters J; Biozentrum, University of Basel, Switzerland.
FEBS Lett ; 590(2): 279-87, 2016 Jan.
Article in En | MEDLINE | ID: mdl-26823173
ABSTRACT
Coronins constitute a family of conserved proteins expressed in all eukaryotes that have been implicated in the regulation of a wide variety of cellular activities. Recent work showed an essential role for coronin 1 in the modulation of the cAMP/PKA pathway in neurons through the interaction of coronin 1 with the G protein subtype Gαs in a stimulus-dependent manner, but the molecular mechanism regulating coronin 1-Gαs interaction remains unclear. We here show that phosphorylation of coronin 1 on Thr(418/424) by cyclin-dependent kinase (CDK) 5 activity was responsible for coronin 1-Gαs association and the modulation of cAMP production. Together these results show an essential role for CDK5 activity in promoting the coronin 1-dependent cAMP/PKA pathway.
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Full text: 1 Database: MEDLINE Main subject: Signal Transduction / Cyclic AMP-Dependent Protein Kinases / Cyclin-Dependent Kinase 5 / Microfilament Proteins Limits: Animals Language: En Journal: FEBS Lett Year: 2016 Type: Article Affiliation country: Switzerland
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Full text: 1 Database: MEDLINE Main subject: Signal Transduction / Cyclic AMP-Dependent Protein Kinases / Cyclin-Dependent Kinase 5 / Microfilament Proteins Limits: Animals Language: En Journal: FEBS Lett Year: 2016 Type: Article Affiliation country: Switzerland