Peptide binding to a bacterial signal peptidase visualized by peptide tethering and carrier-driven crystallization.

Ting, Yi Tian; Harris, Paul W R; Batot, Gaelle; Brimble, Margaret A; Baker, Edward N; Young, Paul G

Ting, Yi Tian; Harris, Paul W R; Batot, Gaelle; Brimble, Margaret A; Baker, Edward N; Young, Paul G.

Affiliation

Ting YT; School of Biological Sciences, The University of Auckland, Auckland 1142, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland 1142, New Zealand.
Harris PW; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland 1142, New Zealand; School of Chemical Sciences, The University of Auckland, Auckland 1142, New Zealand.
Batot G; School of Biological Sciences, The University of Auckland , Auckland 1142, New Zealand.
Brimble MA; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland 1142, New Zealand; School of Chemical Sciences, The University of Auckland, Auckland 1142, New Zealand.
Baker EN; School of Biological Sciences, The University of Auckland, Auckland 1142, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland 1142, New Zealand.
Young PG; School of Biological Sciences, The University of Auckland, Auckland 1142, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland 1142, New Zealand.

IUCrJ ; 3(Pt 1): 10-9, 2016 Jan 01.

Article in En | MEDLINE | ID: mdl-26870377

Key words

Gram-positive pathogen; crystal structures; enzyme mechanisms; peptide complexes; peptide tethering; protein structure; signal peptidase; structural biology

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