Pharmacological or Genetic Activation of Hsp70 Protects against Loss of Parkin Function.

Zhang, Cheng-Wu; Adeline, Henry Basil; Chai, Bing-Han; Hong, Eugenia T E; Ng, Chee-Hoe; Lim, Kah-Leong

Zhang, Cheng-Wu; Adeline, Henry Basil; Chai, Bing-Han; Hong, Eugenia T E; Ng, Chee-Hoe; Lim, Kah-Leong.

Affiliation

Zhang CW; Neurodegeneration Research Laboratory, National Neuroscience Institute, Singapore, Singapore.

Neurodegener Dis ; 16(5-6): 304-16, 2016.

Article in En | MEDLINE | ID: mdl-26886023

Subject(s)

HSP70 Heat-Shock Proteins/metabolism; Parkinson Disease/metabolism; Ubiquitin-Protein Ligases/genetics; Animals; Autophagy/drug effects; Benzoquinones/administration & dosage; Cell Line, Tumor; Drosophila; Humans; Lactams, Macrocyclic/administration & dosage; Mice; Mitochondria/metabolism; Neurons/drug effects; Neurons/metabolism; Neuroprotective Agents/administration & dosage; Parkinson Disease/genetics; Parkinson Disease/pathology; Phenotype; Proteasome Endopeptidase Complex/metabolism

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Full text: 1 Database: MEDLINE Main subject: Parkinson Disease / HSP70 Heat-Shock Proteins / Ubiquitin-Protein Ligases Limits: Animals / Humans Language: En Journal: Neurodegener Dis Journal subject: NEUROLOGIA Year: 2016 Type: Article Affiliation country: Singapore

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