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A potent and selective inhibitor targeting human and murine 12/15-LOX.
Armstrong, Michelle M; Freedman, Cody J; Jung, Joo Eun; Zheng, Yi; Kalyanaraman, Chakrapani; Jacobson, Matthew P; Simeonov, Anton; Maloney, David J; van Leyen, Klaus; Jadhav, Ajit; Holman, Theodore R.
Affiliation
  • Armstrong MM; Chemistry and Biochemistry Department, University of California, Santa Cruz, CA 95060, United States.
  • Freedman CJ; Chemistry and Biochemistry Department, University of California, Santa Cruz, CA 95060, United States.
  • Jung JE; Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, United States.
  • Zheng Y; Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, United States.
  • Kalyanaraman C; Department of Pharmaceutical Chemistry, School of Pharmacy, University of California San Francisco, San Francisco, CA 94143, United States.
  • Jacobson MP; Department of Pharmaceutical Chemistry, School of Pharmacy, University of California San Francisco, San Francisco, CA 94143, United States.
  • Simeonov A; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, MSC 3370, Bethesda, MD 20892, United States.
  • Maloney DJ; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, MSC 3370, Bethesda, MD 20892, United States.
  • van Leyen K; Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, United States.
  • Jadhav A; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, MSC 3370, Bethesda, MD 20892, United States.
  • Holman TR; Chemistry and Biochemistry Department, University of California, Santa Cruz, CA 95060, United States. Electronic address: holman@ucsc.edu.
Bioorg Med Chem ; 24(6): 1183-90, 2016 Mar 15.
Article in En | MEDLINE | ID: mdl-26899595
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Full text: 1 Database: MEDLINE Main subject: Arachidonate 12-Lipoxygenase / Arachidonate 15-Lipoxygenase / Lipoxygenase Inhibitors Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2016 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: Arachidonate 12-Lipoxygenase / Arachidonate 15-Lipoxygenase / Lipoxygenase Inhibitors Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2016 Type: Article Affiliation country: United States