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Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models.
Karuppagounder, Saravanan S; Alim, Ishraq; Khim, Soah J; Bourassa, Megan W; Sleiman, Sama F; John, Roseleen; Thinnes, Cyrille C; Yeh, Tzu-Lan; Demetriades, Marina; Neitemeier, Sandra; Cruz, Dana; Gazaryan, Irina; Killilea, David W; Morgenstern, Lewis; Xi, Guohua; Keep, Richard F; Schallert, Timothy; Tappero, Ryan V; Zhong, Jian; Cho, Sunghee; Maxfield, Frederick R; Holman, Theodore R; Culmsee, Carsten; Fong, Guo-Hua; Su, Yijing; Ming, Guo-li; Song, Hongjun; Cave, John W; Schofield, Christopher J; Colbourne, Frederick; Coppola, Giovanni; Ratan, Rajiv R.
Affiliation
  • Karuppagounder SS; Sperling Center for Hemorrhagic Stroke Recovery, Burke Medical Research Institute, White Plains, NY 10605, USA. Feil Family Brain and Mind Research Institute, Weill Medical College of Cornell University, New York, NY 10065, USA.
  • Alim I; Sperling Center for Hemorrhagic Stroke Recovery, Burke Medical Research Institute, White Plains, NY 10605, USA. Feil Family Brain and Mind Research Institute, Weill Medical College of Cornell University, New York, NY 10065, USA.
  • Khim SJ; Sperling Center for Hemorrhagic Stroke Recovery, Burke Medical Research Institute, White Plains, NY 10605, USA. Feil Family Brain and Mind Research Institute, Weill Medical College of Cornell University, New York, NY 10065, USA.
  • Bourassa MW; Sperling Center for Hemorrhagic Stroke Recovery, Burke Medical Research Institute, White Plains, NY 10605, USA. Feil Family Brain and Mind Research Institute, Weill Medical College of Cornell University, New York, NY 10065, USA.
  • Sleiman SF; Sperling Center for Hemorrhagic Stroke Recovery, Burke Medical Research Institute, White Plains, NY 10605, USA. Feil Family Brain and Mind Research Institute, Weill Medical College of Cornell University, New York, NY 10065, USA.
  • John R; Department of Psychology, University of Alberta, Edmonton, Alberta T6G 2E9, Canada.
  • Thinnes CC; Department of Chemistry, University of Oxford, OX1 3TA Oxford, UK.
  • Yeh TL; Department of Chemistry, University of Oxford, OX1 3TA Oxford, UK.
  • Demetriades M; Department of Chemistry, University of Oxford, OX1 3TA Oxford, UK.
  • Neitemeier S; Institut fuer Pharmakologie and Klinische Pharmazie, Phillips-Universitaet Marburg, D 35032 Marburg, Germany.
  • Cruz D; Department of Biochemistry, Weill Medical College of Cornell University, New York, NY 10065, USA.
  • Gazaryan I; Sperling Center for Hemorrhagic Stroke Recovery, Burke Medical Research Institute, White Plains, NY 10605, USA. Feil Family Brain and Mind Research Institute, Weill Medical College of Cornell University, New York, NY 10065, USA.
  • Killilea DW; Children's Hospital of Oakland, Oakland, CA 94609, USA.
  • Morgenstern L; Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA.
  • Xi G; Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA.
  • Keep RF; Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA.
  • Schallert T; Department of Psychology, University of Texas at Austin, Austin, TX 78712, USA.
  • Tappero RV; Photon Sciences Directorate, Brookhaven National Laboratory, Upton, NY 11973, USA.
  • Zhong J; Sperling Center for Hemorrhagic Stroke Recovery, Burke Medical Research Institute, White Plains, NY 10605, USA. Feil Family Brain and Mind Research Institute, Weill Medical College of Cornell University, New York, NY 10065, USA.
  • Cho S; Sperling Center for Hemorrhagic Stroke Recovery, Burke Medical Research Institute, White Plains, NY 10605, USA. Feil Family Brain and Mind Research Institute, Weill Medical College of Cornell University, New York, NY 10065, USA.
  • Maxfield FR; Department of Biochemistry, Weill Medical College of Cornell University, New York, NY 10065, USA.
  • Holman TR; Chemistry and Biochemistry, Department, University of California at Santa Cruz, Santa Cruz, CA 95064, USA.
  • Culmsee C; Institut fuer Pharmakologie and Klinische Pharmazie, Phillips-Universitaet Marburg, D 35032 Marburg, Germany.
  • Fong GH; Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT 06030, USA.
  • Su Y; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  • Ming GL; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  • Song H; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  • Cave JW; Sperling Center for Hemorrhagic Stroke Recovery, Burke Medical Research Institute, White Plains, NY 10605, USA. Feil Family Brain and Mind Research Institute, Weill Medical College of Cornell University, New York, NY 10065, USA.
  • Schofield CJ; Department of Chemistry, University of Oxford, OX1 3TA Oxford, UK.
  • Colbourne F; Department of Psychology, University of Alberta, Edmonton, Alberta T6G 2E9, Canada.
  • Coppola G; Department of Psychiatry, University of California at Los Angeles, CA 90095, USA.
  • Ratan RR; Sperling Center for Hemorrhagic Stroke Recovery, Burke Medical Research Institute, White Plains, NY 10605, USA. Feil Family Brain and Mind Research Institute, Weill Medical College of Cornell University, New York, NY 10065, USA. rrr2001@med.cornell.edu.
Sci Transl Med ; 8(328): 328ra29, 2016 Mar 02.
Article in En | MEDLINE | ID: mdl-26936506
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Full text: 1 Database: MEDLINE Main subject: Oxygen / Brain / Procollagen-Proline Dioxygenase / Intracranial Hemorrhages / Activating Transcription Factor 4 / Molecular Targeted Therapy / Neurons Type of study: Prognostic_studies Limits: Animals Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2016 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: Oxygen / Brain / Procollagen-Proline Dioxygenase / Intracranial Hemorrhages / Activating Transcription Factor 4 / Molecular Targeted Therapy / Neurons Type of study: Prognostic_studies Limits: Animals Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2016 Type: Article Affiliation country: United States