4-Phenylbutyric Acid Reveals Good Beneficial Effects on Vital Organ Function via Anti-Endoplasmic Reticulum Stress in Septic Rats.

Liu, Liangming; Wu, Huiling; Zang, JiaTao; Yang, Guangming; Zhu, Yu; Wu, Yue; Chen, Xiangyun; Lan, Dan; Li, Tao

Liu, Liangming; Wu, Huiling; Zang, JiaTao; Yang, Guangming; Zhu, Yu; Wu, Yue; Chen, Xiangyun; Lan, Dan; Li, Tao.

Affiliation

Liu L; All authors: State Key Laboratory of Trauma, Burns and Combined Injury, Second Department of Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing, P.R. China.

Crit Care Med ; 44(8): e689-701, 2016 08.

Article in En | MEDLINE | ID: mdl-26958745

Subject(s)

Endoplasmic Reticulum Stress/drug effects; Phenylbutyrates/pharmacology; Shock, Septic/drug therapy; Animals; Apoptosis/drug effects; Caspases/biosynthesis; Cytokines/metabolism; Disease Models, Animal; Female; Glutathione Peroxidase/biosynthesis; Hemodynamics; Lipopolysaccharides/pharmacology; Male; Myocytes, Cardiac/pathology; NF-kappa B/biosynthesis; Organ Dysfunction Scores; Oxidative Stress/drug effects; Rats; Rats, Sprague-Dawley; Shock, Septic/physiopathology; Superoxide Dismutase/biosynthesis

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Full text: 1 Database: MEDLINE Main subject: Phenylbutyrates / Shock, Septic / Endoplasmic Reticulum Stress Type of study: Prognostic_studies Limits: Animals Language: En Journal: Crit Care Med Year: 2016 Type: Article

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