The possible role of the tumour necrosis factor polymorphisms and human leucocyte antigens in the development of prostate cancer.
Int J Immunogenet
; 43(3): 143-50, 2016 Jun.
Article
in En
| MEDLINE
| ID: mdl-27102235
ABSTRACT
The cause of prostate cancer (PC), one of the most common cancers found among ageing men, remains unclear, but genetic predisposition is believed to play a major role in its aetiology. The aim of the study was to examine HLA genes polymorphism and TNF polymorphisms in PC development. Patients diagnosed with PC (N = 113) and 150 healthy individuals were tested for HLA-A, HLA-B and HLA-DRB1 genes and for TNFa, TNFb and TNFd microsatellites. The comparison of patients and controls revealed a positive association of HLA-DRB1*12, TNFa2 and TNFb5, and a negative association of HLA-DRB1*13 and TNFb4 with PC. A division of patients into groups according to age, pre-operative PSA level, Gleason score (GS) and involvement of prostatic capsule, seminal vesicles or bladder neck and perineural invasion of PC demonstrated the following a positive correlation of HLA-DRB1*12 and a negative correlation of HLA-DRB1*13 with younger patients (<65 years), GS > 7 and the positive association of prostatic capsule, seminal vesicles, bladder neck and perineural invasion of PC; TNFb4 allele's negative association with older patients displaying higher PSA levels, higher GS and positive surrounding tissue involvement; positive association of TNFb5 allele for both older and younger patients. Investigation of HLA genes and TNF microsatellites demonstrated a possible role of HLA-DRB1 and TNF regions in PC aetiology.
Full text:
1
Database:
MEDLINE
Main subject:
Prostatic Neoplasms
/
Lymphotoxin-alpha
/
Tumor Necrosis Factor-alpha
/
HLA-DRB1 Chains
Type of study:
Prognostic_studies
Limits:
Aged
/
Aged80
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Int J Immunogenet
Journal subject:
ALERGIA E IMUNOLOGIA
/
GENETICA
Year:
2016
Type:
Article
Affiliation country:
Croatia