Role of DHA in aging-related changes in mouse brain synaptic plasma membrane proteome.

Sidhu, Vishaldeep K; Huang, Bill X; Desai, Abhishek; Kevala, Karl; Kim, Hee-Yong

Sidhu, Vishaldeep K; Huang, Bill X; Desai, Abhishek; Kevala, Karl; Kim, Hee-Yong.

Affiliation

Sidhu VK; Laboratory of Molecular Signaling, DICBR, NIAAA, NIH, Bethesda, MD, USA.
Huang BX; Laboratory of Molecular Signaling, DICBR, NIAAA, NIH, Bethesda, MD, USA.
Desai A; Laboratory of Molecular Signaling, DICBR, NIAAA, NIH, Bethesda, MD, USA.
Kevala K; Laboratory of Molecular Signaling, DICBR, NIAAA, NIH, Bethesda, MD, USA.
Kim HY; Laboratory of Molecular Signaling, DICBR, NIAAA, NIH, Bethesda, MD, USA. Electronic address: hykim@nih.gov.

Neurobiol Aging ; 41: 73-85, 2016 May.

Article in En | MEDLINE | ID: mdl-27103520

Subject(s)

Aging/genetics; Aging/metabolism; Brain/metabolism; Docosahexaenoic Acids/metabolism; Docosahexaenoic Acids/physiology; Membrane Proteins/genetics; Membrane Proteins/metabolism; Proteome; Synapses/physiology; Synaptic Transmission/genetics; Synaptic Transmission/physiology; Aging/psychology; Animals; Cognitive Dysfunction/drug therapy; Cognitive Dysfunction/etiology; Down-Regulation; Fatty Acids, Omega-3/administration & dosage; Female; Male; Membrane Proteins/physiology; Memory; Mice, Inbred C57BL; Pregnancy; Recognition, Psychology

Key words

Aging-related changes; DHA; MSbased protein quantitation; Mass spectrometry; Neurotransmission; Recognition memory; Synaptic plasma membrane proteins

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Full text: 1 Database: MEDLINE Main subject: Synapses / Brain / Aging / Docosahexaenoic Acids / Synaptic Transmission / Proteome / Membrane Proteins Type of study: Etiology_studies Limits: Animals / Pregnancy Language: En Journal: Neurobiol Aging Year: 2016 Type: Article Affiliation country: United States

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