Hypoxia regulates TRAIL sensitivity of colorectal cancer cells through mitochondrial autophagy.

Knoll, Gertrud; Bittner, Sebastian; Kurz, Maria; Jantsch, Jonathan; Ehrenschwender, Martin

Knoll, Gertrud; Bittner, Sebastian; Kurz, Maria; Jantsch, Jonathan; Ehrenschwender, Martin.

Affiliation

Knoll G; Institute of Clinical Microbiology and Hygiene, University Hospital Regensburg, 93053 Regensburg, Germany.
Bittner S; Institute of Clinical Microbiology and Hygiene, University Hospital Regensburg, 93053 Regensburg, Germany.
Kurz M; Institute of Clinical Microbiology and Hygiene, University Hospital Regensburg, 93053 Regensburg, Germany.
Jantsch J; Institute of Clinical Microbiology and Hygiene, University Hospital Regensburg, 93053 Regensburg, Germany.
Ehrenschwender M; Institute of Clinical Microbiology and Hygiene, University Hospital Regensburg, 93053 Regensburg, Germany.

Oncotarget ; 7(27): 41488-41504, 2016 Jul 05.

Article in En | MEDLINE | ID: mdl-27166192

Subject(s)

Autophagy/physiology; Colorectal Neoplasms/drug therapy; Drug Resistance, Neoplasm; Hypoxia/physiopathology; Mitochondria/physiology; TNF-Related Apoptosis-Inducing Ligand/therapeutic use; Apoptosis/drug effects; Apoptosis/genetics; Autophagy/drug effects; Autophagy/genetics; Cell Line, Tumor; Colorectal Neoplasms/genetics; Colorectal Neoplasms/pathology; Drug Resistance, Neoplasm/genetics; HCT116 Cells; HEK293 Cells; HT29 Cells; Humans; Hypoxia/genetics; Hypoxia/metabolism; Hypoxia-Inducible Factor 1, alpha Subunit/genetics; Hypoxia-Inducible Factor 1, alpha Subunit/physiology; Signal Transduction/drug effects; Signal Transduction/genetics; X-Linked Inhibitor of Apoptosis Protein/genetics; X-Linked Inhibitor of Apoptosis Protein/physiology

Key words

SMAC mimetic; TRAIL; death receptor; hypoxia

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Full text: 1 Database: MEDLINE Main subject: Autophagy / Colorectal Neoplasms / Drug Resistance, Neoplasm / TNF-Related Apoptosis-Inducing Ligand / Hypoxia / Mitochondria Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Oncotarget Year: 2016 Type: Article Affiliation country: Germany

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