Molecular mechanisms in H2O2-induced increase in AT1 receptor gene expression in cardiac fibroblasts: A role for endogenously generated Angiotensin II.

Anupama, V; George, Mereena; Dhanesh, Sivadasan Bindu; Chandran, Aneesh; James, Jackson; Shivakumar, K

Anupama, V; George, Mereena; Dhanesh, Sivadasan Bindu; Chandran, Aneesh; James, Jackson; Shivakumar, K.

Affiliation

Anupama V; Division of Cellular and Molecular Cardiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum 695011, Kerala, India.
George M; Division of Cellular and Molecular Cardiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum 695011, Kerala, India.
Dhanesh SB; Neuro Stem Cell Biology, Neurobiology Division, Rajiv Gandhi Center for Biotechnology, Trivandrum 695014, Kerala, India.
Chandran A; Bacterial and Parasite Disease Biology, Tropical Disease Biology, Rajiv Gandhi Center for Biotechnology, Trivandrum 695014, Kerala, India.
James J; Neuro Stem Cell Biology, Neurobiology Division, Rajiv Gandhi Center for Biotechnology, Trivandrum 695014, Kerala, India.
Shivakumar K; Division of Cellular and Molecular Cardiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum 695011, Kerala, India. Electronic address: shivak@sctimst.ac.in.

J Mol Cell Cardiol ; 97: 295-305, 2016 08.

Article in En | MEDLINE | ID: mdl-27208880

Subject(s)

Angiotensin II/metabolism; Gene Expression Regulation/drug effects; Hydrogen Peroxide/pharmacology; Myofibroblasts/drug effects; Myofibroblasts/metabolism; Receptor, Angiotensin, Type 1/genetics; Animals; MAP Kinase Signaling System/drug effects; Male; Models, Biological; NADPH Oxidases/metabolism; NF-kappa B/metabolism; Oxidative Stress/drug effects; Rats; Reactive Oxygen Species/metabolism; Receptor, Angiotensin, Type 1/metabolism; Signal Transduction/drug effects; Transcription Factor AP-1/metabolism; Transcription, Genetic/drug effects; p38 Mitogen-Activated Protein Kinases/metabolism

Key words

AT1R; Angiotensin II; Cardiac fibroblasts; Collagen; Oxidative stress

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Full text: 1 Database: MEDLINE Main subject: Angiotensin II / Gene Expression Regulation / Receptor, Angiotensin, Type 1 / Myofibroblasts / Hydrogen Peroxide Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Mol Cell Cardiol Year: 2016 Type: Article Affiliation country: India

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