Prenatal ultrasound factors and genetic disorders in pregnancies complicated by polyhydramnios.
Prenat Diagn
; 36(8): 726-30, 2016 Aug.
Article
in En
| MEDLINE
| ID: mdl-27247190
ABSTRACT
OBJECTIVE:
The objective of the study is to examine the incidence of chromosomal or genetic abnormalities in pregnancies complicated by polyhydramnios and to assess the value of prenatal ultrasound findings in the prediction of cases associated with such disorders.METHODS:
We searched the prenatal records of all patients delivered in our hospital with a diagnosis of polyhydramnios during pregnancy. For each case, maternal characteristics, ultrasound findings, and genetic testing results were recorded. A postnatal follow-up program of at least 6 months, including a clinical assessment by a clinical geneticist, was carried out in all cases.RESULTS:
On a total of 195 cases, genetic testing and clinical examination identified a chromosomal or genetic disease in 26 (13.3%) cases. Multivariate analysis demonstrated that significant predictors of a genetic disorder were a deepest vertical pocket of amniotic fluid of ≥13.0 cm (OR 4.306, 95%CI 1.535-12.079) and reduced fetal movements (OR 25.084, 95%CI 4.577-137.461), but not the presence of a structural defect.CONCLUSION:
A postnatal clinical follow-up program can reveal chromosomal or genetic disorders in about 13% of neonates with a prenatal diagnosis of polyhydramnios. The severity of polyhydramnios and the reduction of fetal movements are independently associated with the presence of such diseases. © 2016 John Wiley & Sons, Ltd.
Full text:
1
Database:
MEDLINE
Main subject:
Congenital Abnormalities
/
Polyhydramnios
/
Chromosome Disorders
/
Amniotic Fluid
/
Genetic Diseases, Inborn
Type of study:
Diagnostic_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Newborn
/
Pregnancy
Language:
En
Journal:
Prenat Diagn
Year:
2016
Type:
Article
Affiliation country:
Italy