DNA Repair Deficiency Is Common in Advanced Prostate Cancer: New Therapeutic Opportunities.

Dhawan, Mallika; Ryan, Charles J; Ashworth, Alan

Dhawan, Mallika; Ryan, Charles J; Ashworth, Alan.

Affiliation

Dhawan M; Helen Diller Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, USA.
Ryan CJ; Helen Diller Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, USA.
Ashworth A; Helen Diller Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, USA Alan.Ashworth@ucsf.edu.

Oncologist ; 21(8): 940-5, 2016 08.

Article in En | MEDLINE | ID: mdl-27317574

Subject(s)

Ataxia Telangiectasia Mutated Proteins/genetics; BRCA1 Protein/genetics; BRCA2 Protein/genetics; DNA Repair-Deficiency Disorders/drug therapy; Prostatic Neoplasms, Castration-Resistant/drug therapy; DNA Repair/genetics; DNA Repair-Deficiency Disorders/complications; DNA Repair-Deficiency Disorders/genetics; DNA Repair-Deficiency Disorders/pathology; Humans; Male; Phthalazines/therapeutic use; Piperazines/therapeutic use; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use; Prostatic Neoplasms, Castration-Resistant/complications; Prostatic Neoplasms, Castration-Resistant/genetics; Prostatic Neoplasms, Castration-Resistant/pathology

Key words

BRCA; DNA repair; PARP inhibitors; Prostate cancer

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Full text: 1 Database: MEDLINE Main subject: BRCA1 Protein / BRCA2 Protein / DNA Repair-Deficiency Disorders / Prostatic Neoplasms, Castration-Resistant / Ataxia Telangiectasia Mutated Proteins Type of study: Risk_factors_studies Limits: Humans / Male Language: En Journal: Oncologist Journal subject: NEOPLASIAS Year: 2016 Type: Article Affiliation country: United States

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