Antineoplastic Combined Chemotherapy Protocols; Imidazoles/therapeutic use; Lung Neoplasms/drug therapy; Lung Neoplasms/genetics; Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors; Proto-Oncogene Proteins p21(ras)/genetics; Pyridazines/therapeutic use; Pyridones/therapeutic use; Pyrimidinones/therapeutic use; Receptor, Fibroblast Growth Factor, Type 1/antagonists & inhibitors; Adenocarcinoma/drug therapy; Adenocarcinoma/genetics; Adenocarcinoma/pathology; Adenocarcinoma of Lung; Animals; Cell Death/drug effects; Cell Proliferation/drug effects; Colonic Neoplasms/genetics; Colonic Neoplasms/pathology; Disease Models, Animal; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Enzyme Activation/drug effects; Feedback, Physiological; Female; Humans; Imidazoles/pharmacology; Lung Neoplasms/pathology; MAP Kinase Signaling System/drug effects; Mice; Mutant Proteins/genetics; Mutation; Pancreatic Neoplasms/genetics; Pancreatic Neoplasms/pathology; Phosphorylation/drug effects; Pyridazines/pharmacology; Pyridones/pharmacology; Pyrimidinones/pharmacology; Receptor, Fibroblast Growth Factor, Type 1/metabolism; Xenograft Model Antitumor Assays