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Deep brain stimulation and climbing fiber synaptic pathology in essential tremor.
Kuo, Sheng-Han; Lin, Chi-Ying; Wang, Jie; Liou, Jyun-You; Pan, Ming-Kai; Louis, Ravi J; Wu, Wei-Pu; Gutierrez, Jesus; Louis, Elan D; Faust, Phyllis L.
Affiliation
  • Kuo SH; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY. sk3295@columbia.edu.
  • Lin CY; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY.
  • Wang J; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY.
  • Liou JY; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY.
  • Pan MK; Department of Basic and Community Nursing, School of Nursing, Nanjing Medical University, Nanjing, Jiangsu Province, China.
  • Louis RJ; Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY.
  • Wu WP; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY.
  • Gutierrez J; Department of Medical Research, National Taiwan University, Taipei, Taiwan.
  • Louis ED; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY.
  • Faust PL; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY.
Ann Neurol ; 80(3): 461-5, 2016 09.
Article in En | MEDLINE | ID: mdl-27422481
ABSTRACT
Essential tremor (ET) patients have abnormal climbing fiber (CF) synapses in the parallel fiber territory in the cerebellum, and these abnormal CF synapses are inversely correlated with tremor severity. We therefore examined CF synaptic pathology in ET cases with and without thalamic deep brain stimulation (DBS) and assessed the association with tremor severity. We found that CF synaptic pathology was inversely correlated with tremor severity in ET cases without DBS, and this correlation disappeared in ET cases with DBS. Our data suggest that DBS might have effects in modulating excitatory synapses in ET cerebellum, in addition to its symptomatic effects on tremor. Ann Neurol 2016;80461-465.
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Full text: 1 Database: MEDLINE Main subject: Synapses / Cerebellar Diseases / Essential Tremor / Deep Brain Stimulation / Nerve Fibers Limits: Aged / Aged80 / Female / Humans / Male Language: En Journal: Ann Neurol Year: 2016 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Synapses / Cerebellar Diseases / Essential Tremor / Deep Brain Stimulation / Nerve Fibers Limits: Aged / Aged80 / Female / Humans / Male Language: En Journal: Ann Neurol Year: 2016 Type: Article