Creatine kinase inhibition lowers systemic arterial blood pressure in spontaneously hypertensive rats: a randomized controlled trial.

Karamat, Fares A; Oudman, Inge; Haan, Yentl C; van Kuilenburg, Andre B P; Leen, Rene; Danser, Jan A H; Leijten, Frank P J; Ris-Stalpers, Carrie; van Montfrans, Gert A; Clark, Joseph F; Brewster, Lizzy M

Karamat, Fares A; Oudman, Inge; Haan, Yentl C; van Kuilenburg, Andre B P; Leen, Rene; Danser, Jan A H; Leijten, Frank P J; Ris-Stalpers, Carrie; van Montfrans, Gert A; Clark, Joseph F; Brewster, Lizzy M.

Affiliation

Karamat FA; aDepartment of Vascular Medicine bLaboratory for Genetic and Metabolic Diseases, Academic Medical Center, University of Amsterdam, Amsterdam cDepartment of Vascular Medicine and Pharmacology, Erasmus Medical Center, Rotterdam dDepartment of Obstetrics and Gynaecology and Reproductive Biology Laboratory eDepartment of Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands fThe Vontz Center for Molecular Studies, University of Cincinnati, Cincinnati, Ohio,

J Hypertens ; 34(12): 2418-2426, 2016 12.

Article in En | MEDLINE | ID: mdl-27512977

Subject(s)

Blood Pressure/drug effects; Creatine Kinase/antagonists & inhibitors; Guanidines/pharmacology; Propionates/pharmacology; Protein Kinase Inhibitors/pharmacology; Animals; Arteries/drug effects; Arteries/physiopathology; Diuresis/drug effects; Hypertension/drug therapy; Kidney/metabolism; Male; Random Allocation; Rats; Rats, Inbred SHR; Renin/metabolism; Vasodilation/drug effects

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Database: MEDLINE Main subject: Propionates / Blood Pressure / Creatine Kinase / Protein Kinase Inhibitors / Guanidines Type of study: Guideline / Prognostic_studies Limits: Animals Language: En Journal: J Hypertens Year: 2016 Type: Article

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