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MicroRNA signatures predict dysregulated vitamin D receptor and calcium pathways status in limb girdle muscle dystrophies (LGMD) 2A/2B.
Aguennouz, M; Lo Giudice, C; Licata, N; Rodolico, C; Musumeci, O; Fanin, M; Migliorato, A; Ragusa, M; Macaione, V; Di Giorgio, R M; Angelini, C; Toscano, A.
Affiliation
  • Aguennouz M; Department of Clinical and Experimental Medicine, University of Messina, Italy.
  • Lo Giudice C; Department of Clinical and Experimental Medicine, University of Messina, Italy.
  • Licata N; Department of Clinical and Experimental Medicine, University of Messina, Italy.
  • Rodolico C; Department of Clinical and Experimental Medicine, University of Messina, Italy.
  • Musumeci O; Department of Clinical and Experimental Medicine, University of Messina, Italy.
  • Fanin M; Neurological Clinic, University of Padua, Italy.
  • Migliorato A; Department of Clinical and Experimental Medicine, University of Messina, Italy.
  • Ragusa M; Department of Biomedical and Biotechnological Sciences Biology, Genetics and Bioinformatics Unit, University of Catania, Italy.
  • Macaione V; Department of Clinical and Experimental Medicine, University of Messina, Italy.
  • Di Giorgio RM; Department of Clinical and Experimental Medicine, University of Messina, Italy.
  • Angelini C; Neurological Clinic, University of Padua, Italy.
  • Toscano A; Department of Clinical and Experimental Medicine, University of Messina, Italy.
Cell Biochem Funct ; 34(6): 414-22, 2016 Aug.
Article in En | MEDLINE | ID: mdl-27558075
miRNA expression profile and predicted pathways involved in selected limb-girdle muscular dystrophy (LGMD)2A/2B patients were investigated. A total of 187 miRNAs were dysregulated in all patients, with six miRNAs showing opposite regulation in LGMD2A versus LGMD2B patients. Silico analysis evidence: (1) a cluster of the dysregulated miRNAs resulted primarily involved in inflammation and calcium metabolism, and (2) two genes predicted as controlled by calcium-assigned miRNAs (Vitamin D Receptor gene and Guanine Nucleotide Binding protein beta polypeptide 1gene) showed an evident upregulation in LGMD2B patients, in accordance with miRNA levels. Our data support alterations in calcium pathway status in LGMD 2A/B, suggesting myofibre calcium imbalance as a potential therapeutic target. Copyright © 2016 John Wiley & Sons, Ltd.
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Full text: 1 Database: MEDLINE Main subject: Signal Transduction / Calcium / Receptors, Calcitriol / Gene Expression Profiling / MicroRNAs / Muscular Dystrophies, Limb-Girdle Type of study: Prognostic_studies / Risk_factors_studies Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male / Middle aged Language: En Journal: Cell Biochem Funct Year: 2016 Type: Article Affiliation country: Italy
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Full text: 1 Database: MEDLINE Main subject: Signal Transduction / Calcium / Receptors, Calcitriol / Gene Expression Profiling / MicroRNAs / Muscular Dystrophies, Limb-Girdle Type of study: Prognostic_studies / Risk_factors_studies Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male / Middle aged Language: En Journal: Cell Biochem Funct Year: 2016 Type: Article Affiliation country: Italy