Rapid development of a DNA vaccine for Zika virus.
Science
; 354(6309): 237-240, 2016 10 14.
Article
in En
| MEDLINE
| ID: mdl-27708058
ABSTRACT
Zika virus (ZIKV) was identified as a cause of congenital disease during the explosive outbreak in the Americas and Caribbean that began in 2015. Because of the ongoing fetal risk from endemic disease and travel-related exposures, a vaccine to prevent viremia in women of childbearing age and their partners is imperative. We found that vaccination with DNA expressing the premembrane and envelope proteins of ZIKV was immunogenic in mice and nonhuman primates, and protection against viremia after ZIKV challenge correlated with serum neutralizing activity. These data not only indicate that DNA vaccination could be a successful approach to protect against ZIKV infection, but also suggest a protective threshold of vaccine-induced neutralizing activity that prevents viremia after acute infection.
Full text:
1
Database:
MEDLINE
Main subject:
Viral Vaccines
/
Viral Envelope Proteins
/
Vaccines, DNA
/
Zika Virus
/
Zika Virus Infection
/
Immunogenicity, Vaccine
Limits:
Animals
Language:
En
Journal:
Science
Year:
2016
Type:
Article
Affiliation country:
United States