Investigation on the Cutaneous Change Induced by Face-Lifting Monodirectional Barbed Polydioxanone Thread.
Dermatol Surg
; 43(1): 74-80, 2017 Jan.
Article
in En
| MEDLINE
| ID: mdl-27748691
ABSTRACT
BACKGROUND:
Owing to its potentially greater mechanical force on the implanted tissue, barbed thread is frequently used in face-lifting procedures. However, the long-term durability thereof remains controversial. Moreover, reports on underlying histologic and molecular changes resulting from face-lifting procedures are scarce.OBJECTIVE:
To evaluate histologic and molecular changes induced by absorbable, barbed face-lifting thread in an animal model. MATERIALS ANDMETHODS:
Fragments of monofilament, monodirectionally barbed polydioxanone thread were implanted in dorsal skin from 12 guinea pigs. Tissue samples were harvested at 1, 3, and 7 months thereafter. Histopathologic analysis and quantification of Type 1 collagen and transforming growth factor beta 1 (TGF-ß1) levels were performed.RESULTS:
Implantation of a single fragment induced fibrous capsule around the thread. Tissue reactions were strongest at 1 month after implantation, showing marked infiltration of inflammatory cells and fibroblasts, which gradually decreased. On molecular analysis, Type 1 collagen and TGF-ß1 levels were significantly increased, compared to normal skin, throughout the 7-month study period.CONCLUSION:
Our results suggest that implantation of barbed thread induces strong anchorage to skin tissue. Quantitative analysis of collagen and its downstream signaling molecule TGF-ß supports the long-term durability of the thread. Therefore, the authors expect potential beneficial effect for rejuvenation on its clinical application.
Full text:
1
Database:
MEDLINE
Main subject:
Skin
/
Sutures
/
Foreign-Body Reaction
/
Polydioxanone
/
Collagen Type I
/
Transforming Growth Factor beta1
Type of study:
Etiology_studies
/
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Dermatol Surg
Journal subject:
DERMATOLOGIA
Year:
2017
Type:
Article