Comparative biodistribution and safety profiling of olmesartan medoxomil oil-in-water oral nanoemulsion.

Gorain, Bapi; Choudhury, Hira; Tekade, Rakesh Kumar; Karan, Saumen; Jaisankar, P; Pal, Tapan Kumar

Gorain, Bapi; Choudhury, Hira; Tekade, Rakesh Kumar; Karan, Saumen; Jaisankar, P; Pal, Tapan Kumar.

Affiliation

Gorain B; Bioequivalence Study Centre, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India; Faculty of Pharmacy, Lincoln University College, Kuala Lumpur, Malaysia. Electronic address: bapi@lincoln.edu.my.
Choudhury H; Bioequivalence Study Centre, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India; Department of Pharmaceutical Technology, School of Pharmacy, International Medical University, Malaysia.
Tekade RK; National Institute of Pharmaceutical Education and Research (NIPER) - Ahmedabad, Department of Pharmaceutics, Opposite Air Force Station Palaj-Basan Road, Gandhinagar, Gujarat 382355, India.
Karan S; Division of Pharmacology, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India.
Jaisankar P; Department of Chemistry, Indian Institute of Chemical Biology, Jadavpur, Kolkata, India.
Pal TK; Bioequivalence Study Centre, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India. Electronic address: proftkpal@gmail.com.

Regul Toxicol Pharmacol ; 82: 20-31, 2016 Dec.

Article in En | MEDLINE | ID: mdl-27815174

Subject(s)

Angiotensin II Type 1 Receptor Blockers/pharmacokinetics; Antihypertensive Agents/pharmacokinetics; Drug Carriers; Nanoparticles; Oils/chemistry; Olmesartan Medoxomil/pharmacokinetics; Water/chemistry; Administration, Oral; Angiotensin II Type 1 Receptor Blockers/administration & dosage; Angiotensin II Type 1 Receptor Blockers/chemistry; Angiotensin II Type 1 Receptor Blockers/toxicity; Animals; Antihypertensive Agents/administration & dosage; Antihypertensive Agents/chemistry; Antihypertensive Agents/toxicity; Biomarkers/blood; Body Weight/drug effects; Brain/metabolism; Chromatography, Liquid; Drinking/drug effects; Drug Compounding; Eating/drug effects; Emulsions; Male; Nanomedicine/methods; Olmesartan Medoxomil/administration & dosage; Olmesartan Medoxomil/chemistry; Olmesartan Medoxomil/toxicity; Organ Size/drug effects; Permeability; Rats, Wistar; Reproducibility of Results; Risk Assessment; Tandem Mass Spectrometry; Tissue Distribution; Toxicity Tests, Subchronic

Key words

Brain penetration; Hematological parameters; Histopathological characteristics; Olmesartan nanoemulsion; Sub-chronic toxicity; Tissue distribution

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Oils / Drug Carriers / Water / Angiotensin II Type 1 Receptor Blockers / Nanoparticles / Olmesartan Medoxomil / Antihypertensive Agents Type of study: Etiology_studies / Risk_factors_studies Limits: Animals Language: En Journal: Regul Toxicol Pharmacol Year: 2016 Type: Article

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google