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Discovery of TAK-659 an orally available investigational inhibitor of Spleen Tyrosine Kinase (SYK).
Lam, Betty; Arikawa, Yasuyoshi; Cramlett, Joshua; Dong, Qing; de Jong, Ron; Feher, Victoria; Grimshaw, Charles E; Farrell, Pamela J; Hoffman, Isaac D; Jennings, Andy; Jones, Benjamin; Matuszkiewicz, Jennifer; Miura, Joanne; Miyake, Hiroshi; Natala, Srinivasa Reddy; Shi, Lihong; Takahashi, Masashi; Taylor, Ewan; Wyrick, Corey; Yano, Jason; Zalevsky, Jonathan; Nie, Zhe.
Affiliation
  • Lam B; Takeda California, Inc., 10410 Science Center Drive, San Diego, CA 92121, USA. Electronic address: betty.lam@takeda.com.
  • Arikawa Y; Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Cramlett J; PolyScientific Consulting Inc., 4624 Aragon Dr, San Diego, CA 92115, USA.
  • Dong Q; FronThera US Pharmaceuticals, 11526 Sorrento Valley Road, Suite D, San Diego, CA 92121, USA.
  • de Jong R; Takeda California, Inc., 10410 Science Center Drive, San Diego, CA 92121, USA.
  • Feher V; Schrödinger, Inc., 5820 Oberlin Drive, Ste. 203, San Diego, CA 92121, USA.
  • Grimshaw CE; Takeda California, Inc., 10410 Science Center Drive, San Diego, CA 92121, USA.
  • Farrell PJ; Takeda California, Inc., 10410 Science Center Drive, San Diego, CA 92121, USA.
  • Hoffman ID; Takeda California, Inc., 10410 Science Center Drive, San Diego, CA 92121, USA.
  • Jennings A; Takeda California, Inc., 10410 Science Center Drive, San Diego, CA 92121, USA.
  • Jones B; Takeda California, Inc., 10410 Science Center Drive, San Diego, CA 92121, USA.
  • Matuszkiewicz J; Celgene Quanticel Research, 9393 Towne Center Drive, Suite 110, San Diego, CA 92121, USA.
  • Miura J; Takeda California, Inc., 10410 Science Center Drive, San Diego, CA 92121, USA.
  • Miyake H; Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Natala SR; Neuropore Therapies, 10835 Road to Cure, Suite 230, San Diego, CA 92121, USA.
  • Shi L; Celgene Quanticel Research, 9393 Towne Center Drive, Suite 110, San Diego, CA 92121, USA.
  • Takahashi M; Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Taylor E; Takeda California, Inc., 10410 Science Center Drive, San Diego, CA 92121, USA.
  • Wyrick C; Takeda California, Inc., 10410 Science Center Drive, San Diego, CA 92121, USA.
  • Yano J; Beryllium Discovery, 3 Preston Ct., Bedford, MA 01730, USA.
  • Zalevsky J; Nektar Therapeutics, 455 Mission Bay Boulevard South, San Francisco, CA 94158, USA.
  • Nie Z; Celgene Quanticel Research, 9393 Towne Center Drive, Suite 110, San Diego, CA 92121, USA.
Bioorg Med Chem Lett ; 26(24): 5947-5950, 2016 12 15.
Article in En | MEDLINE | ID: mdl-27839918
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Full text: 1 Database: MEDLINE Main subject: Pyrimidines / Pyrrolidinones / Protein Kinase Inhibitors / Drug Discovery / Syk Kinase Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2016 Type: Article
Fulltext
Add to My VHL
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Full text: 1 Database: MEDLINE Main subject: Pyrimidines / Pyrrolidinones / Protein Kinase Inhibitors / Drug Discovery / Syk Kinase Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2016 Type: Article