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Lowered H3K27me3 and DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas.
Bayliss, Jill; Mukherjee, Piali; Lu, Chao; Jain, Siddhant U; Chung, Chan; Martinez, Daniel; Sabari, Benjamin; Margol, Ashley S; Panwalkar, Pooja; Parolia, Abhijit; Pekmezci, Melike; McEachin, Richard C; Cieslik, Marcin; Tamrazi, Benita; Garcia, Benjamin A; La Rocca, Gaspare; Santi, Mariarita; Lewis, Peter W; Hawkins, Cynthia; Melnick, Ari; David Allis, C; Thompson, Craig B; Chinnaiyan, Arul M; Judkins, Alexander R; Venneti, Sriram.
Affiliation
  • Bayliss J; Department of Pathology, University of Michigan, Ann Arbor, MI 48104, USA.
  • Mukherjee P; Epigenomics Core Facility, Weill Medical College of Cornell University, New York, NY 10065, USA.
  • Lu C; Laboratory of Chromatin Biology and Epigenetics, Rockefeller University, New York, NY 10065, USA.
  • Jain SU; Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53715, USA.
  • Chung C; Department of Pathology, University of Michigan, Ann Arbor, MI 48104, USA.
  • Martinez D; Department of Pathology, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Sabari B; Laboratory of Chromatin Biology and Epigenetics, Rockefeller University, New York, NY 10065, USA.
  • Margol AS; Department of Pediatrics, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA.
  • Panwalkar P; Department of Pathology, University of Michigan, Ann Arbor, MI 48104, USA.
  • Parolia A; Department of Pathology, University of Michigan, Ann Arbor, MI 48104, USA.
  • Pekmezci M; Michigan Center for Translational Pathology, Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48104, USA.
  • McEachin RC; Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Cieslik M; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48104, USA.
  • Tamrazi B; Department of Pathology, University of Michigan, Ann Arbor, MI 48104, USA.
  • Garcia BA; Michigan Center for Translational Pathology, Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48104, USA.
  • La Rocca G; Department of Radiology, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA.
  • Santi M; Epigenetics Program, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Lewis PW; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Hawkins C; Department of Pathology, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Melnick A; Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53715, USA.
  • David Allis C; Arthur and Sonia Labatt Brain Tumour Research Centre and Division of Pathology, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Thompson CB; Faculty of Medicine, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
  • Chinnaiyan AM; Epigenomics Core Facility, Weill Medical College of Cornell University, New York, NY 10065, USA.
  • Judkins AR; Laboratory of Chromatin Biology and Epigenetics, Rockefeller University, New York, NY 10065, USA.
  • Venneti S; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Sci Transl Med ; 8(366): 366ra161, 2016 11 23.
Article in En | MEDLINE | ID: mdl-27881822
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Full text: 1 Database: MEDLINE Main subject: Brain Neoplasms / Histones / DNA Methylation / Ependymoma Type of study: Prognostic_studies Limits: Child / Humans Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2016 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: Brain Neoplasms / Histones / DNA Methylation / Ependymoma Type of study: Prognostic_studies Limits: Child / Humans Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2016 Type: Article Affiliation country: United States