Diterpenoids of the Cassane Type from Caesalpinia decapetala.
J Nat Prod
; 79(12): 3134-3142, 2016 Dec 23.
Article
in En
| MEDLINE
| ID: mdl-27966950
ABSTRACT
Eighteen compounds, including eight new cassane-type furanoditerpenoids, 3ß-hydroxyphanginin H (1), 3ß-acetoxyphanginin H (2), 7ß-acetoxyphanginin H (3), 7ß-hydroxyphanginin H (4), 4-epi-3ß-hydroxycaesalpinilinn (5), 4-epi-3ß-acetoxycaesalpinilinn (6), 20-acetoxytaepeenin D (7), and tomocin E (8), along with 10 known compounds (9-18) were isolated from the roots of Caesalpinia decapetala. Compounds 1-13 were isolated from C. decapetala for the first time. The new compounds with their absolute configurations were determined by extensive spectroscopic analysis, single-crystal X-ray diffraction, and electronic circular dichroism calculations. Compounds 1, 4, 5, 7, and 11 exhibited inhibitory activities against the SW1990 human pancreatic cancer cell line with IC50 values ranging from 2.9 to 8.9 µM.
Full text:
1
Database:
MEDLINE
Main subject:
Drugs, Chinese Herbal
/
Caesalpinia
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Diterpenes
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Antineoplastic Agents, Phytogenic
Limits:
Animals
/
Humans
/
Male
Language:
En
Journal:
J Nat Prod
Year:
2016
Type:
Article