Structure and lipid-binding properties of the kindlin-3 pleckstrin homology domain.

Ni, Tao; Kalli, Antreas C; Naughton, Fiona B; Yates, Luke A; Naneh, Omar; Kozorog, Mirijam; Anderluh, Gregor; Sansom, Mark S P; Gilbert, Robert J C

Ni, Tao; Kalli, Antreas C; Naughton, Fiona B; Yates, Luke A; Naneh, Omar; Kozorog, Mirijam; Anderluh, Gregor; Sansom, Mark S P; Gilbert, Robert J C.

Affiliation

Ni T; Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, U.K.
Kalli AC; Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K.
Naughton FB; Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K.
Yates LA; Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, U.K.
Naneh O; Department for Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.
Kozorog M; Department for Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.
Anderluh G; Department for Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.
Sansom MS; Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K. mark.sansom@bioch.ox.ac.uk gilbert@strubi.ox.ac.uk.
Gilbert RJ; Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, U.K. mark.sansom@bioch.ox.ac.uk gilbert@strubi.ox.ac.uk.

Biochem J ; 474(4): 539-556, 2017 02 15.

Article in En | MEDLINE | ID: mdl-27974389

Subject(s)

Cytoskeletal Proteins/chemistry; Phosphatidylcholines/chemistry; Phosphatidylinositols/chemistry; Phosphatidylserines/chemistry; Pleckstrin Homology Domains; Receptors, Cytoplasmic and Nuclear/chemistry; Amino Acid Sequence; Animals; Binding Sites; Cloning, Molecular; Crystallography, X-Ray; Cytoskeletal Proteins/genetics; Cytoskeletal Proteins/metabolism; Escherichia coli/genetics; Escherichia coli/metabolism; Gene Expression; Kinetics; Mice; Molecular Dynamics Simulation; Phosphatidylcholines/metabolism; Phosphatidylinositols/metabolism; Phosphatidylserines/metabolism; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Receptors, Cytoplasmic and Nuclear/genetics; Receptors, Cytoplasmic and Nuclear/metabolism; Recombinant Proteins/chemistry; Recombinant Proteins/genetics; Recombinant Proteins/metabolism; Sequence Alignment; Sequence Homology, Amino Acid

Key words

PH domain; X-ray crystallography; lipid clustering; molecular dynamics; surface plasmon resonance

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Full text: 1 Database: MEDLINE Main subject: Phosphatidylcholines / Phosphatidylinositols / Phosphatidylserines / Receptors, Cytoplasmic and Nuclear / Cytoskeletal Proteins / Pleckstrin Homology Domains Limits: Animals Language: En Journal: Biochem J Year: 2017 Type: Article Affiliation country: United kingdom

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