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Winner's Curse Correction and Variable Thresholding Improve Performance of Polygenic Risk Modeling Based on Genome-Wide Association Study Summary-Level Data.
Shi, Jianxin; Park, Ju-Hyun; Duan, Jubao; Berndt, Sonja T; Moy, Winton; Yu, Kai; Song, Lei; Wheeler, William; Hua, Xing; Silverman, Debra; Garcia-Closas, Montserrat; Hsiung, Chao Agnes; Figueroa, Jonine D; Cortessis, Victoria K; Malats, Núria; Karagas, Margaret R; Vineis, Paolo; Chang, I-Shou; Lin, Dongxin; Zhou, Baosen; Seow, Adeline; Matsuo, Keitaro; Hong, Yun-Chul; Caporaso, Neil E; Wolpin, Brian; Jacobs, Eric; Petersen, Gloria M; Klein, Alison P; Li, Donghui; Risch, Harvey; Sanders, Alan R; Hsu, Li; Schoen, Robert E; Brenner, Hermann; Stolzenberg-Solomon, Rachael; Gejman, Pablo; Lan, Qing; Rothman, Nathaniel; Amundadottir, Laufey T; Landi, Maria Teresa; Levinson, Douglas F; Chanock, Stephen J; Chatterjee, Nilanjan.
Affiliation
  • Shi J; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America.
  • Park JH; Department of Statistics, Dongguk University, Seoul, Korea.
  • Duan J; Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, North Shore University Health System Research Institute, University of Chicago Pritzker School of Medicine, Evanston, Illinois, United States of America.
  • Berndt ST; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America.
  • Moy W; Dept. of Statistics, Northern Illinois University, DeKalb, Illinois, United States of America.
  • Yu K; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America.
  • Song L; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America.
  • Wheeler W; Information Management Services, Inc., Rockville, Maryland, United States of America.
  • Hua X; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America.
  • Silverman D; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America.
  • Garcia-Closas M; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America.
  • Hsiung CA; Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
  • Figueroa JD; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America.
  • Cortessis VK; Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Medical School, Edinburgh, United Kingdom.
  • Malats N; Department of Preventive Medicine and Department of Obstetrics and Gynecology, USC Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.
  • Karagas MR; Norris Comprehensive Cancer Center, USC Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.
  • Vineis P; Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
  • Chang IS; Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, United States of America.
  • Lin D; Human Genetics Foundation, Turin, Italy.
  • Zhou B; MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom.
  • Seow A; National Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan.
  • Matsuo K; Department of Etiology & Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
  • Hong YC; State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
  • Caporaso NE; Department of Epidemiology, School of Public Health, China Medical University, Shenyang, China.
  • Wolpin B; Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
  • Jacobs E; Division of Molecular Medicine, Aichi Cancer Center Research Institute, Chikusa-ku, Nagoya, Japan.
  • Petersen GM; Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
  • Klein AP; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America.
  • Li D; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America.
  • Risch H; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.
  • Sanders AR; Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, United States of America.
  • Hsu L; Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America.
  • Schoen RE; Department of Oncology, the Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
  • Brenner H; Department of Epidemiology, the Bloomberg School of Public Health, Baltimore, Maryland, United States of America.
  • Stolzenberg-Solomon R; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
  • Gejman P; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Chatterjee N; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America.
PLoS Genet ; 12(12): e1006493, 2016 Dec.
Article in En | MEDLINE | ID: mdl-28036406
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Full text: 1 Database: MEDLINE Main subject: Genetic Predisposition to Disease / Multifactorial Inheritance / Genome-Wide Association Study / Models, Genetic Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: PLoS Genet Journal subject: GENETICA Year: 2016 Type: Article Affiliation country: United States
Fulltext
Add to My VHL
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Full text: 1 Database: MEDLINE Main subject: Genetic Predisposition to Disease / Multifactorial Inheritance / Genome-Wide Association Study / Models, Genetic Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: PLoS Genet Journal subject: GENETICA Year: 2016 Type: Article Affiliation country: United States