Effects of functional CYP2C8,CYP2C9,CYP3A5,and ABCB1 genetic variants on the pharmacokinetics of insulin sensitizer pioglitazone in Chinese Han individuals.

Yin, Sheng-Ju; Qi, Hui-Min; Wang, Xin; Zhang, Pu; Lu, Yuan; Wei, Min-Ji; Li, Pu; Qi, Guang-Zhao; Lou, Ya-Qing; Lu, Chuang; Zhang, Guo-Liang

Yin, Sheng-Ju; Qi, Hui-Min; Wang, Xin; Zhang, Pu; Lu, Yuan; Wei, Min-Ji; Li, Pu; Qi, Guang-Zhao; Lou, Ya-Qing; Lu, Chuang; Zhang, Guo-Liang.

Affiliation

Yin SJ; aDepartment of Pharmacology,School of Basic Medical Sciences, Peking University bDepartment of Pharmacokinetics, Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, China cDepartment of Drug Metabolism & Pharmacokinetics, Biogen, Cambridge, Massachusetts, USA.

Pharmacogenet Genomics ; 27(4): 125-134, 2017 04.

Article in En | MEDLINE | ID: mdl-28099407

Subject(s)

Asian People/genetics; Gene Regulatory Networks; Hypoglycemic Agents/administration & dosage; Polymorphism, Single Nucleotide; Thiazolidinediones/administration & dosage; ATP Binding Cassette Transporter, Subfamily B/genetics; Administration, Oral; Adult; Asian People/ethnology; China/ethnology; Cytochrome P-450 CYP2C8/genetics; Cytochrome P-450 CYP2C9/genetics; Cytochrome P-450 CYP3A/genetics; Female; Genotype; Humans; Hypoglycemic Agents/pharmacokinetics; Male; Pharmacogenomic Variants; Pioglitazone; Thiazolidinediones/pharmacokinetics; Young Adult

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Full text: 1 Database: MEDLINE Main subject: Polymorphism, Single Nucleotide / Thiazolidinediones / Asian People / Gene Regulatory Networks / Hypoglycemic Agents Limits: Adult / Female / Humans / Male Country/Region as subject: Asia Language: En Journal: Pharmacogenet Genomics Journal subject: FARMACOLOGIA / GENETICA MEDICA Year: 2017 Type: Article Affiliation country: United States

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