Human ß-defensin 3 increases the TLR9-dependent response to bacterial DNA.

McGlasson, Sarah L; Semple, Fiona; MacPherson, Heather; Gray, Mohini; Davidson, Donald J; Dorin, Julia R

McGlasson, Sarah L; Semple, Fiona; MacPherson, Heather; Gray, Mohini; Davidson, Donald J; Dorin, Julia R.

Affiliation

McGlasson SL; MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, UK.
Semple F; MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, UK.
MacPherson H; MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, UK.
Gray M; MRC Centre for Inflammation Research, QMRI, University of Edinburgh, Edinburgh, UK.
Davidson DJ; MRC Centre for Inflammation Research, QMRI, University of Edinburgh, Edinburgh, UK.
Dorin JR; MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, UK.

Eur J Immunol ; 47(4): 658-664, 2017 04.

Article in En | MEDLINE | ID: mdl-28102569

Subject(s)

Dendritic Cells/immunology; Escherichia coli/immunology; Leukocytes, Mononuclear/immunology; Toll-Like Receptor 9/metabolism; beta-Defensins/metabolism; Animals; Cells, Cultured; DNA, Bacterial/immunology; Host-Pathogen Interactions; Humans; Immunity, Innate; Membrane Proteins/metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Toll-Like Receptor 9/genetics

Key words

Antimicrobial peptide; Dendritic cells; Plasmacytoid dendritic cells; Toll like receptor 9; Type I interferon; ß-Defensin

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Full text: 1 Database: MEDLINE Main subject: Dendritic Cells / Leukocytes, Mononuclear / Beta-Defensins / Escherichia coli / Toll-Like Receptor 9 Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Eur J Immunol Year: 2017 Type: Article Affiliation country: United kingdom

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