Hereditary cancer syndromes in Latino populations: genetic characterization and surveillance guidelines.
Hered Cancer Clin Pract
; 15: 3, 2017.
Article
in En
| MEDLINE
| ID: mdl-28127413
ABSTRACT
Hereditary cancer predisposition syndromes comprise approximately 10% of diagnosed cancers; however, familial forms are believed to account for up to 30% of some cancers. In Hispanics, the most commonly diagnosed hereditary cancers include colorectal cancer syndromes such as, Lynch Syndrome, Familial Adenomatous Polyposis, and hereditary breast and ovarian cancer syndromes. Although the incidence of hereditary cancers is low, patients diagnosed with hereditary cancer syndromes are at high-risk for developing secondary cancers. Furthermore, the productivity loss that occurs after cancer diagnosis in these high-risk patients has a negative socio-economic impact. This review summarizes the genetic basis, phenotype characteristics, and the National Comprehensive Cancer Network's screening, testing, and surveillance guidelines for the leading hereditary cancer syndromes. The aim of this review is to promote a better understanding of cancer genetics and genetic testing in Hispanic patients.
Full text:
1
Database:
MEDLINE
Type of study:
Guideline
/
Screening_studies
Language:
En
Journal:
Hered Cancer Clin Pract
Year:
2017
Type:
Article