Delayed de-induction of CYP2C9 compared to CYP3A after discontinuation of rifampicin: Report of two casesâ©.

Shibata, Soichi; Takahashi, Harumi; Baba, Akiyasu; Takeshita, Kei; Atsuda, Koichiro; Matsubara, Hajime; Echizen, Hirotoshi

Delayed de-induction of CYP2C9 compared to CYP3A after discontinuation of rifampicin: Report of two casesâ©.

Shibata, Soichi; Takahashi, Harumi; Baba, Akiyasu; Takeshita, Kei; Atsuda, Koichiro; Matsubara, Hajime; Echizen, Hirotoshi.

Int J Clin Pharmacol Ther ; 55(5): 449-452, 2017 May.

Article in En | MEDLINE | ID: mdl-28157069

Subject(s)

Antibiotics, Antitubercular/adverse effects; Anticoagulants/administration & dosage; Cytochrome P-450 CYP2C9 Inducers/adverse effects; Cytochrome P-450 CYP2C9/biosynthesis; Cytochrome P-450 CYP3A Inducers/adverse effects; Cytochrome P-450 CYP3A/biosynthesis; Rifampin/adverse effects; Warfarin/administration & dosage; Aged; Aged, 80 and over; Antibiotics, Antitubercular/administration & dosage; Anticoagulants/adverse effects; Anticoagulants/pharmacokinetics; Blood Coagulation/drug effects; Cytochrome P-450 CYP2C9 Inducers/administration & dosage; Cytochrome P-450 CYP3A Inducers/administration & dosage; Drug Dosage Calculations; Drug Interactions; Drug Monitoring/methods; Enzyme Induction; Female; Humans; International Normalized Ratio; Polypharmacy; Prothrombin Time; Rifampin/administration & dosage; Substrate Specificity; Warfarin/adverse effects; Warfarin/pharmacokinetics

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Full text: 1 Database: MEDLINE Main subject: Rifampin / Warfarin / Cytochrome P-450 CYP3A / Cytochrome P-450 CYP2C9 / Cytochrome P-450 CYP2C9 Inducers / Cytochrome P-450 CYP3A Inducers / Antibiotics, Antitubercular / Anticoagulants Type of study: Guideline Limits: Aged / Aged80 / Female / Humans Language: En Journal: Int J Clin Pharmacol Ther Journal subject: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Year: 2017 Type: Article

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