Potentiating SLC transporter activity: Emerging drug discovery opportunities.

Rives, Marie-Laure; Javitch, Jonathan A; Wickenden, Alan D

Rives, Marie-Laure; Javitch, Jonathan A; Wickenden, Alan D.

Affiliation

Rives ML; Molecular and Cellular Pharmacology, Discovery Sciences, Janssen R&D, San Diego, CA 92121, United States.
Javitch JA; Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, United States; Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, United States.
Wickenden AD; Molecular and Cellular Pharmacology, Discovery Sciences, Janssen R&D, San Diego, CA 92121, United States. Electronic address: awickend@its.jnj.com.

Biochem Pharmacol ; 135: 1-11, 2017 07 01.

Article in En | MEDLINE | ID: mdl-28214518

Subject(s)

Drug Discovery/methods; Membrane Transport Proteins/metabolism; Solute Carrier Proteins/metabolism; Animals; Biological Transport/drug effects; Biological Transport/physiology; Cell Membrane/drug effects; Cell Membrane/metabolism; Drug Discovery/trends; Humans; Membrane Transport Proteins/chemistry; Protein Structure, Secondary; Protein Structure, Tertiary; Protein Transport/drug effects; Protein Transport/physiology; Selective Serotonin Reuptake Inhibitors/metabolism; Selective Serotonin Reuptake Inhibitors/pharmacology; Solute Carrier Proteins/chemistry

Key words

Glutamate; Monoamine; Potentiator; SLC; Transporter

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Full text: 1 Database: MEDLINE Main subject: Membrane Transport Proteins / Drug Discovery / Solute Carrier Proteins Limits: Animals / Humans Language: En Journal: Biochem Pharmacol Year: 2017 Type: Article Affiliation country: United States

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