Polygenic risk scores for schizophrenia and bipolar disorder associate with addiction.
Addict Biol
; 23(1): 485-492, 2018 01.
Article
in En
| MEDLINE
| ID: mdl-28231610
ABSTRACT
We use polygenic risk scores (PRSs) for schizophrenia (SCZ) and bipolar disorder (BPD) to predict smoking, and addiction to nicotine, alcohol or drugs in individuals not diagnosed with psychotic disorders. Using PRSs for 144 609 subjects, including 10 036 individuals admitted for in-patient addiction treatment and 35 754 smokers, we find that diagnoses of various substance use disorders and smoking associate strongly with PRSs for SCZ (P = 5.3 × 10-50 -1.4 × 10-6 ) and BPD (P = 1.7 × 10-9 -1.9 × 10-3 ), showing shared genetic etiology between psychosis and addiction. Using standardized scores for SCZ and BPD scaled to a unit increase doubling the risk of the corresponding disorder, the odds ratios for alcohol and substance use disorders range from 1.19 to 1.31 for the SCZ-PRS, and from 1.07 to 1.29 for the BPD-PRS. Furthermore, we show that as regular smoking becomes more stigmatized and less prevalent, these biological risk factors gain importance as determinants of the behavior.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Schizophrenia
/
Tobacco Use Disorder
/
Bipolar Disorder
/
Substance-Related Disorders
/
Cigarette Smoking
Type of study:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Europa
Language:
En
Journal:
Addict Biol
Journal subject:
TRANSTORNOS RELACIONADOS COM SUBSTANCIAS
Year:
2018
Type:
Article
Affiliation country:
Iceland