MYC: Master Regulator of Immune Privilege.
Trends Immunol
; 38(4): 298-305, 2017 04.
Article
in En
| MEDLINE
| ID: mdl-28233639
ABSTRACT
Cancers are often initiated by genetic events that activate proto-oncogenes or inactivate tumor-suppressor genes. These events are also crucial for sustained tumor cell proliferation and survival, a phenomenon described as oncogene addiction. In addition to this cell-intrinsic role, recent evidence indicates that oncogenes also directly regulate immune responses, leading to immunosuppression. Expression of many oncogenes or loss of tumor suppressors induces the expression of immune checkpoints that regulate the immune response, such as PD-L1. We discuss here how oncogenes, and in particular MYC, suppress immune surveillance, and how oncogene-targeted therapies may restore the immune response against tumors.
Full text:
1
Database:
MEDLINE
Main subject:
Proto-Oncogene Proteins c-myc
/
Tumor Suppressor Proteins
/
Carcinogenesis
/
Immune Tolerance
/
Neoplasms
Limits:
Animals
/
Humans
Language:
En
Journal:
Trends Immunol
Journal subject:
ALERGIA E IMUNOLOGIA
Year:
2017
Type:
Article
Affiliation country:
United States