Downregulation of GATA1 drives impaired hematopoiesis in primary myelofibrosis.

Gilles, Laure; Arslan, Ahmet Dirim; Marinaccio, Christian; Wen, Qiang Jeremy; Arya, Priyanka; McNulty, Maureen; Yang, Qiong; Zhao, Jonathan C; Konstantinoff, Katerina; Lasho, Terra; Pardanani, Animesh; Stein, Brady; Plo, Isabelle; Sundaravel, Sriram; Wickrema, Amittha; Migliaccio, Annarita; Gurbuxani, Sandeep; Vainchenker, William; Platanias, Leonidas C; Tefferi, Ayalew; Crispino, John D

Gilles, Laure; Arslan, Ahmet Dirim; Marinaccio, Christian; Wen, Qiang Jeremy; Arya, Priyanka; McNulty, Maureen; Yang, Qiong; Zhao, Jonathan C; Konstantinoff, Katerina; Lasho, Terra; Pardanani, Animesh; Stein, Brady; Plo, Isabelle; Sundaravel, Sriram; Wickrema, Amittha; Migliaccio, Annarita; Gurbuxani, Sandeep; Vainchenker, William; Platanias, Leonidas C; Tefferi, Ayalew; Crispino, John D.

J Clin Invest ; 127(4): 1316-1320, 2017 Apr 03.

Article in En | MEDLINE | ID: mdl-28240607

Subject(s)

Down-Regulation; GATA1 Transcription Factor/biosynthesis; Megakaryocytes/metabolism; Primary Myelofibrosis/metabolism; Thrombopoiesis; Animals; Chromosome Deletion; Chromosomes, Human, Pair 5/genetics; Chromosomes, Human, Pair 5/metabolism; GATA1 Transcription Factor/genetics; Humans; Megakaryocytes/pathology; Mice; Primary Myelofibrosis/genetics; Primary Myelofibrosis/pathology; Ribosomal Proteins/biosynthesis; Ribosomal Proteins/genetics

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Full text: 1 Database: MEDLINE Main subject: Megakaryocytes / Down-Regulation / Thrombopoiesis / GATA1 Transcription Factor / Primary Myelofibrosis Limits: Animals / Humans Language: En Journal: J Clin Invest Year: 2017 Type: Article

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