Dynamic coupling between TRPV4 and Ca2+-activated SK1/3 and IK1 K+ channels plays a critical role in regulating the K+-secretory BK channel in kidney collecting duct cells.

Li, Yue; Hu, Hongxiang; Tian, Jin-Bin; Zhu, Michael X; O'Neil, Roger G

Dynamic coupling between TRPV4 and Ca²⁺-activated SK1/3 and IK1 K⁺ channels plays a critical role in regulating the K⁺-secretory BK channel in kidney collecting duct cells.

Li, Yue; Hu, Hongxiang; Tian, Jin-Bin; Zhu, Michael X; O'Neil, Roger G.

Affiliation

Li Y; Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas.
Hu H; Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas.
Tian JB; Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas.
Zhu MX; Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas.
O'Neil RG; Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas roger.g.oneil@uth.tmc.edu.

Am J Physiol Renal Physiol ; 312(6): F1081-F1089, 2017 06 01.

Article in En | MEDLINE | ID: mdl-28274924

Subject(s)

Calcium/metabolism; Intermediate-Conductance Calcium-Activated Potassium Channels/metabolism; Kidney Tubules, Collecting/metabolism; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits/metabolism; Potassium/metabolism; Small-Conductance Calcium-Activated Potassium Channels/metabolism; TRPV Cation Channels/metabolism; Animals; Calcium Channel Agonists/pharmacology; Calcium Signaling; Cells, Cultured; Intermediate-Conductance Calcium-Activated Potassium Channels/antagonists & inhibitors; Kidney Tubules, Collecting/drug effects; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits/antagonists & inhibitors; Membrane Potentials; Mice; Potassium Channel Blockers/pharmacology; Small-Conductance Calcium-Activated Potassium Channels/antagonists & inhibitors; TRPV Cation Channels/agonists

Key words

BK (KCNMA1); IK1 (KCNN4); K+ secretion; KCa channels; SK1 (KCNN1); SK3 (KCNN3); TRPV4; cortical collecting duct; intracellular Ca2+; mCCDcl1 cells; membrane potential

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Full text: 1 Database: MEDLINE Main subject: Potassium / Calcium / Intermediate-Conductance Calcium-Activated Potassium Channels / Large-Conductance Calcium-Activated Potassium Channel alpha Subunits / Small-Conductance Calcium-Activated Potassium Channels / TRPV Cation Channels / Kidney Tubules, Collecting Type of study: Prognostic_studies Limits: Animals Language: En Journal: Am J Physiol Renal Physiol Journal subject: FISIOLOGIA / NEFROLOGIA Year: 2017 Type: Article

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