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Polymorphisms of cancer stem cell marker gene CD133 are associated with susceptibility and prognosis of gastric cancer.
Jia, Zhi-Fang; Wu, Yan-Hua; Cao, Dong-Hui; Cao, Xue-Yuan; Jiang, Jing; Zhou, Bao-Sen.
Affiliation
  • Jia ZF; Department of Epidemiology, School of Public Health, China Medical University, Shenyang 110112, PR China.
  • Wu YH; Division of Clinical Research, First Hospital of Jilin University, Changchun 130021, PR China.
  • Cao DH; Division of Clinical Research, First Hospital of Jilin University, Changchun 130021, PR China.
  • Cao XY; Division of Clinical Research, First Hospital of Jilin University, Changchun 130021, PR China.
  • Jiang J; Department of Gastrointestinal Surgery, First Hospital of Jilin University, Changchun 130021, PR China.
  • Zhou BS; Division of Clinical Research, First Hospital of Jilin University, Changchun 130021, PR China.
Future Oncol ; 13(11): 979-989, 2017 May.
Article in En | MEDLINE | ID: mdl-28326835
ABSTRACT

AIM:

This study was aimed to investigate the associations between single nucleotide polymorphisms of cancer stem cell marker genes, CD44 and CD133, and susceptibility and prognosis of gastric cancer. PATIENTS &

METHODS:

Five single nucleotide polymorphisms in CD44 and CD133 genes were genotyped in 898 gastric cancer cases and 992 controls.

RESULTS:

The A/C or C/C genotypes of CD133 rs2240688 were associated with decreased risk of gastric cancer comparing with the A/A genotype (odds ratio 0.81; 95% CI 0.67-0.97; p = 0.023). The T allele of CD133 rs3130 predicted a worse survival for gastric cancer patients receiving tumorectomy (hazard ratio 1.28; 95% CI 1.04-1.58; p = 0.020), independent from tumor node metastasis stage, vessel invasion and postoperational chemotherapy.

CONCLUSION:

 CD133 polymorphisms are promising biomarkers for genetic susceptibility and prognosis prediction of gastric cancer.
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Full text: 1 Database: MEDLINE Main subject: Stomach Neoplasms / Neoplastic Stem Cells / Biomarkers, Tumor / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide / AC133 Antigen Type of study: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Future Oncol Year: 2017 Type: Article
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Stomach Neoplasms / Neoplastic Stem Cells / Biomarkers, Tumor / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide / AC133 Antigen Type of study: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Future Oncol Year: 2017 Type: Article